摘要
Objective:To study the effect of selective arterial chemoembolization combined with local radiotherapy on the malignant biological behavior of advanced lung cancer.Methods:A total of 76 patients with advanced lung cancer treated in our hospital between May 2011 and July 2015 were collected, their treatment and related test results were retrospectively analyzed, and then they were divided into the control group who accepted intravenous chemotherapy combined with local radiotherapy and the observation group who accepted selective arterial chemoembolization combined with local radiotherapy. After treatment, immune scatter turbidimetry was used to detect the serum tumor marker levels of both groups, and fluorescence quantitative PCR was used to detect the proliferation, invasion and autophagy gene mRNA expression in lung cancer tissue.Results: After treatment, serum tumor markers CA19-9, CYFRA21-1, GSTP1 and CHI3L1 levels of observation group were significantly lower than those of control group;proliferation genes HOXB7 and TEM8 mRNA expression in lung cancer tissue of observation group were significantly lower than those of control group while TCF21 mRNA expression was significantly higher than that of control group;invasion gene EFEMP1 mRNA expression in lung cancer of observation group was significantly higher than that of control group while PAK4, FoxM1 and NGAL mRNA expression were significantly lower than those of control group;autophagy genes LC3, Beclin-1, pULK, PI3KC3 and MAPLC3 mRNA expression in lung cancer tissue of observation group were significantly higher than those of control group.Conclusion: Selective arterial chemoembolization combined with local radiotherapy can reduce the malignant degree of advanced lung cancer and inhibit lung cancer cell proliferation and invasion.
