摘要
Objective:To explore the effect of human urinary kallikein (HUK) on the neurological function and intracranial hemodynamics in patients with acute cerebral infarction.Methods:A total of 150 patients with acute cerebral infarction who were admitted in our hospital were included in the study and divided into the observation group and the control group with 75 cases in each group according to different treatment protocols. The patients in the two groups were given routine drugs for conservative treatment. On this basis, the patients in the observation group were given HUK. NSE and S-100 protein before treatment, 3, 7, 14, and 28 d after treatment in the two groups were compared. TCD was used to detect the cerebral hemodynamics. NIHSS and BI were used to evaluate the improved degree of neurological function and daily living activities before treatment, 1 and 3 months after treatment.Results: NSE and S-100 protein 3, 7, 14, and 28 d after treatment in the observation group were significantly lower than those in the control group (P<0.05). The blood flow rate of left vertebral artery, right vertebral artery, and basilar artery after treatment in the two groups was significantly elevated (P<0.05). The blood flow rate of left vertebral artery, right vertebral artery, and basilar artery after treatment in the observation group was significantly higher than that in the control group (P<0.05). NIHSS and BI scores 1 and 3 months after treatment in the observation group were significantly superior to those in the control group (P<0.05).Conclusions: HUK can effective reduced the brain tissue injury in patients with acute cerebral infarction, and promote the recovery of neurological function, with an accurate efficacy.
