摘要
目的 比较颞叶癫痫患者术后左乙拉西坦和拉莫三嗪联合用药与丙戊酸钠治疗的疗效及安全性.方法 选择四川大学华西医院2012年8月-2014年8月行手术治疗的186例颞叶癫痫,术后根据所用抗癫痫药物不同分为左乙拉西坦和拉莫三嗪联合用药组98例与丙戊酸钠单药组88例,抗癫痫治疗随访12~48个月,观察疗效及不良反应,计算保留率及不良反应发生率.结果 联合用药组Engel I级率为72.4%(71例),Ⅱ级率为17.3%(17例),Ⅲ级率为7.1%(7例),Ⅳ级率为3.2%(3例);单药组Engel Ⅰ级率为67.0%(59例),Ⅱ级率为21.6%(19例),Ⅲ级率为9.1%(8例),Ⅳ级率为2.3%(2例),两组各级比较差异均无统计学意义(P>0.05).联合用药组保留率和不良反应发生率分别为90.8%(89例)、15.3%(15例),单药组为80.7%(71例)、36.4%(32例),组间比较差异均有统计学意义(P<0.05).结论 颞叶癫痫手术后左乙拉西坦和拉莫三嗪联合使用和丙戊酸钠单药治疗均取得良好的疗效,且左乙拉西坦和拉莫三嗪在保留率及减少不良反应发生率方面更具优势.
Objective To compare the curative efet of levetiracetam combined with lamotrigine and sodium valproate on postoperative patients with temporal lobe epilepsy.Methods A total of 186 postoperative patients with temporal lobe epilepsy during August 2012 to August 2014 in our hospital were divided into levetracetam combined with lamotrigine group(n=98),and sodium valproate group(n=88)based on postoperative dfferent antiepileptie drugs treatment.Antiepileptie treatment were fllowed up for 12~48 months.Curative effect and adverse reaction were observed.Reservation rales and incidence rates of adverse reaction were calculated in the two groups.Results In levetiracetam combined with lamotrigine group,Engel I ratio was 72.4%(71),Engel I ratio was 17.3%(17),Engel I ratio was 7.1%(7),and Engel IV ratio was 3.2%(3);in sodium valproate group,Engel I ratio was 67.0%(59),Engel I ratio was 21.6%(19),Engel I ratio was9.1%(8),and Engel IV ratio was 2.3%(2),and the diference was not stistically significant in the sarme grade of two groups(P>0.05).Reservation rate and incidence rate of adverse reaction in levetiracetam combined with lamotrigine group were 90.8%(89)and 15.3%(15)respectively.While those in sodium valproate group were 80.7%(71)and 36.4%(32)respectively.The differences were statistically significant between the two groups(P<0.05).Conclusions Levetiracetam combined with lamotrigine treatment on postoperative patients with temporal lobe epilepsy may have better curative ffects than sodium valproate treatment,and levetiracetam combined with lamotrigine has its advantage in reservation rate and less adverse reaction.
作者
陈杰
田欢
雷町
CHEN Jie;TIAN Huan;LEI ding(Department of Neursurgery,Sichuan Petroleum Hospital,Chengdu 610213,China;Department of Neurosurgery,West China Hospital of Sichuan Uninersity,Chengdu 610041,China)
出处
《癫痫杂志》
2015年第3期209-211,共3页
Journal of Epilepsy
关键词
颞叶癫痫
术后
左乙拉西坦
拉莫三嗪
丙戊酸钠
疗效比较
Temporal lobe epilepsy
Postoperation
L evetiracetam
Lamotrigine
Sodium valproate
Efficacy comparison
