摘要
目的分析青岛地区先天性心脏病室间隔缺损(VSD)的发病率及危险因素。方法采用前瞻性队列研究设计,纳入2018年8月至2020年6月在青岛地区行产前筛查的孕妇(青岛地区全人口全覆盖)。根据经皮血氧饱和度+心脏听诊诊断产后新生儿VSD,并依据筛选7 d内VSD阳性新生儿的超声心动图进行最终诊断。采用多因素logistic回归模型分析VSD的危险因素。结果共纳入115238名活产儿,其中388例诊断为VSD,发病率为3.37‰。多因素logistic回归分析结果显示,母亲研究生学历(与初中及以下相比)(OR=1.61,95%CI:1.00~2.58,P=0.049)、早产史(OR=2.90,95%CI:1.47~5.70,P=0.002)、先天性心脏病孕育史(OR=5.98,95%CI:2.63~14.73,P<0.001)为新生儿VSD的危险因素;与女性新生儿相比,男性新生儿VSD的总体发病风险较低(OR=0.74,95%CI:0.60~0.91,P=0.005)。结论青岛地区VSD发病率为3.37‰;母亲文化程度高、先天性心脏病孕育史和早产史是新生儿VSD的危险因素,男性新生儿VSD的总体风险较低。
Objective To analyze the incidence and risk factors of ventricular septal defect(VSD)in Qingdao.Methods A prospective cohort study design was used to include pregnant women who underwent prenatal screening in Qingdao between August 2018 and June 2020(the whole population coverage).VSD was diagnosed according to the pulse oxygen saturation and heart auscultation,and the final diagnosis was made according to the echocardiography of VSD positive newborns within postnatal day 7.Results The study included 115238 live births,among which 388 were diagnosed as VSD,with an incidence of 3.37‰.The results of multivariate logistic regression analysis showed that mother with postgraduate level(OR=1.61,95%CI:1.00-2.58,P=0.049)(compared with junior high school and below),preterm birth history(OR=2.90,95%CI:1.47-5.70,P=0.002),and pregnancy history of congenital heart disease(OR=5.98,95%CI:2.63-14.73,P<0.001)were risk factors for VSD.Compared with female infants,the overall risk of VSD in male infants was relatively low(OR=0.74,95%CI:0.60-0.91,P=0.005).Conclusions The incidence of VSD in Qingdao is 3.37‰.The risk factors of VSD include higher maternal education level,pregnancy history of congenital heart disease and preterm birth history.Moreover,the overall risk of VSD in male infants is low.
作者
晁聪
李国菊
汪国兰
武钦
倪伟
邢泉生
Chao Cong;Li Guoju;Wang Guolan;Wu Qin;Ni Wei;Xing Quansheng(Birth Defect Prevention and Control Centre of Qingdao,Women and Children′s Hospital,Qingdao University,Qingdao 266034,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2023年第24期1824-1829,共6页
National Medical Journal of China
基金
国家自然科学基金(82071583)
泰山学者工程(2019)
关键词
室间隔缺损
发病率
危险因素
队列研究
Heart septal defects,ventricular
Incidence
Risk factors
Cohort study
