摘要
病毒性脑(膜)炎是常见的中枢神经系统感染性疾病,是病毒侵袭脑实质与脑膜导致的炎症性疾病。病毒性脑(膜)炎呈世界性分布,临床以急症和重症常见,严重威胁人类健康。多种病毒可导致中枢神经系统感染,包括疱疹病毒、肠道病毒和虫媒病毒等,病原体鉴定仍是病毒性脑(膜)炎在临床上的主要难题。为规范、合理地应用病原体诊断技术开展脑脊液的病毒核酸检测与抗体检测,由国内病毒学、传染病学、临床医学及医学检验等领域的专家组成的专家组,经反复讨论达成本共识,主要从国内外病毒性脑(膜)炎病原种类、检测技术及检测策略等方面进行阐述,并提出针对我国病毒性脑(膜)炎病原体的检测策略和方案,以期为病毒性脑(膜)炎的临床诊断以及疾病预防控制提供参考。
Viral encephalitis(meningitis)is a common infectious disease of the central nervous system(CNS),which is an inflammatory disease caused by viruses invading the brain parenchyma and meninges.It is a global disease and a serious threat to human health as an acute and severe medical condition.CNS infections can be caused by a variety of viruses,including herpes viruses,enteroviruses,and arboviruses,etc.Identification and diagnosis of the pathogens remains a major clinical challenge.In order to standardize the application of nucleic acid and antibody tests of patients with viral encephalitis(meningitis),experts in the field of virology,infectious diseases,clinical medicine and laboratory testing in China reached the consensus after repeated discussions.The current consensus mainly consists of the domestic and foreign pathogen types,the detection techniques,the detection strategies and schemes for Chinese viral encephalitis,thereby providing a reference for the clinical diagnosis and disease prevention and control of viral encephalitis(meningitis).
作者
中国初级卫生保健基金会病原检测专业委员会
中国医疗保健国际交流促进会分子诊断学分会
中国研究型医院学会神经科学专委会脑炎协作组
许松涛
关鸿志
谢正德
范思远
China Primary Health Care Foundation Professional Committee of Pathogen Detection;Molecular Diagnostics Branch of China International Exchange and Promotive Association for Medical and Health Care;Encephalitis Group of the Neuroscience Committee of Chinese Research Hospital Association;Xu Songtao;Guan Hongzhi;Xie Zhengde(不详;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of Neurology,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100005,China;National Children′s Medical Center,Beijing Children′s Hospital,Capital Medical University,Department of Infection and Virus Research,Beijing Institute of Pediatrics,Chinese Academy of Medical Sciences,Beijing 100045,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2023年第9期648-657,共10页
National Medical Journal of China
基金
国家自然科学基金(31900156)
关键词
病毒性脑炎
病毒性脑膜炎
病原体
检测
脑脊液
专家共识
Viral encephalitis
Viral meningitis
Pathogens
Detection
Cerebrospinal fluid
Expert consensus
