摘要
环状RNA(circRNA)是一类新发现的共价闭合环状非编码RNA,具有微小RNA海绵作用、调控基因表达等功能。研究证实circRNA参与多种肿瘤的发生发展,可作为肿瘤诊断和预后评估的生物标志物及治疗靶点。本文就circRNA在头颈部鳞状细胞癌中的表达情况、作用机制等进行综述。
CircRNA(circular RNA)is a new class of covalently closed circular non-coding RNAs,with the function of the microRNA sponge,regulation of gene expression,and other functions.Studies have confirmed that circRNAs are involved in the occurrence and progression of a variety of tumors,and can be used as biomarkers and therapeutic targets for tumor diagnosis and prognosis evaluation.In this paper,the expression and mechanism of circRNA in head and neck squamous cell carcinoma are reviewed.
作者
孙景垚
费晓文
王文龙
李建卫
王玉良
Sun Jingyao;Fei Xiaowen;Wang Wenlong;Li Jianwei;Wang Yuliang(Department of Oral and Maxillofacial Surgery,Yantai Affiliated Hospital of Binzhou Medical University,Yantai 264100,China;Department of Pediatric Stomatology,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,China;Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,China)
出处
《中国医师杂志》
CAS
2022年第10期1594-1597,共4页
Journal of Chinese Physician
基金
山东省自然科学基金(ZR2019PH075)
关键词
RNA
环状
RNA
非编码
头颈鳞癌
生物标记
肿瘤
RNA,circular
RNA,noncoding
Squamous cell carcinoma of head and neck
Biomarkers,tumor
