摘要
胰岛素样生长因子1(IGF-1)是人体最重要、作用最广泛的细胞因子之一,具有促进人体生长发育、物质代谢及细胞分化、增殖等作用。IGF-1的氨基酸序列与胰岛素具有同源性,因此具有与胰岛素相似的降血糖作用。既往研究表明,糖尿病患者血清IGF-1水平较非糖尿病患者低。同时,IGF-1对甲状腺功能有直接或间接的刺激作用,其可与促甲状腺激素(TSH)共同影响碘的摄取及有机化,进而导致甲状腺功能异常。近年来,甲状腺疾病在糖尿病患者中的发病率逐年升高,现将糖尿病患者IGF-1水平与甲状腺疾病的相关性研究进展作一综述。
Insulin-like growth factor 1(IGF-1)is one of the most important and extensive functional cytokines the body.It can promote growth and development,substance metabolism,cell differentiation and proliferation.The amino acid sequence of IGF-1 is homologous to insulin,so it has hypoglycemic effect similar to insulin.Previous studies have shown that serum IGF-1 levels are lower in the people with diabetes than those in the people without diabetes.At the same time,IGF-1 can stimulate thyroid function directly or indirectly,and it can affect iodine uptake and organic synthesis together with the thyrotropin(TSH),leading to abnormal thyroid function.In recent years,the incidence of thyroid disease in patients with diabetes is increasing year by year.This paper reviews the research progress of the correlation between IGF-1 levels and thyroid diseases in diabetic patients.
作者
栾若蔚
张梅
Luan Ruowei;Zhang Mei(College of Clinical Medicine,Jining Medical University,Jining 272013,China;Department of Endocrinology,Affiliated Hospital of Jining Medical University,Jining 272029,China)
出处
《中华诊断学电子杂志》
2022年第2期109-112,共4页
Chinese Journal of Diagnostics(Electronic Edition)
关键词
糖尿病
胰岛素样生长因子1
甲状腺疾病
Diabetes mellitus
Insulin-like growth factor 1
Thyroid diseases
