摘要
心脏和血管疾病(cardiovascular disease,CVD)是威胁人类身体健康和生命安全的主要疾病。神经酰胺作为一种简单的生物活性脂质,是在糖尿病、心脏和血管疾病起致病作用的鞘脂,神经酰胺已被证明在患有心脏和血管疾病个体的许多组织中积累,包括血管系统和心脏。研究表明,神经酰胺与多种心脏和血管疾病的关系密切且互相影响,参与了心脏和血管病的发生和发展,尤其对高血压、冠状动脉粥样硬化型心脏病和心力衰竭预后风险具有重要预测价值。未来需要进一步研究证实降低神经酰胺水平和神经酰胺合成途径中的反应酶是否可减轻心脏和血管疾病的严重程度及其严重后果的发生风险。
Cardiovascular disease(CVD)is a major category of diseases threatening human health and life.Ceramide is a simple bioactive sphingolipid that plays a role in the pathogenesis of diabetes and CVD.Ceramide has been shown to accumulate in many tissues of individuals with CVD,including the vascular system and the heart.In recent years,more and more studies have shown that ceramide is closely related to a variety of CVDs.Ceramide is involved in the occurrence and development of CVD,and has predictive value especially for hypertension,coronary atherosclerotic heart disease,and heart failure.Future studies are needed to confirm whether reducing ceramide levels and the reactive enzymes involved in ceramide synthesis pathways can reduce the severity and risk of serious outcomes in CVD.
作者
张洪
王宏宇
Zhang Hong;Wang Hongyu(Second Clinical School of Medicine,Xinjiang Medical University,Urumqi 830054,China;Center for Vascular Medicine,Peking University Shougang Hospital,Beijing 100144,China)
出处
《中华临床医师杂志（电子版）》
CAS
北大核心
2023年第11期1202-1205,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
2019年度临床重点项目建设项目(2019-Yuan-LC-01)
2020年首都卫生发作科研专项(自主创新)(首发2020-2-6042)
北京市石景山区血管医学重点专科项目(2020-2023)
