摘要
目的探讨血清高敏C反应蛋白(high sensitivity-C reactive protein,hs-CRP)、白介素-6(interleukin-6,IL-6)、肿瘤坏死因子(tumer necrosis factor-α,TNF-α)的水平在心房颤动的发生与维持中的变化及意义。方法心房颤动病人69例,分为3组,阵发性心房颤动组27例,持续性心房颤动组19例,永久性心房颤动组23例,对照组(窦性心律)21例。采用酶联免疫试验检测血清hs-CRP、IL-6、TNF-α表达水平,同时应用心脏超声测量各组病人左心房内径以及左心室射血分数。结果阵发性心房颤动组、持续性心房颤动组、永久性心房颤动组血清hs-CRP、IL-6、TNF-α的水平与对照组比较均增高(P<0.01);持续性及永久性心房颤动组血清hs-CRP、IL-6、TNF-α的水平均高于阵发性心房颤动组(P<0.01);持续性心房颤动组及永久性心房颤动组血清hs-CRP、IL-6、TNF-α的水平之间差异无统计学意义(P>0.05)。持续性心房颤动组、永久性心房颤动组左心房内径明显增大,与窦性心律组比较差异有统计学意义(P<0.01);阵发性心房颤动组与窦性心律组比较,左心房内径虽有增大,但差异无统计学意义(P>0.05)。结论心房颤动病人的血清hs-CRP、IL-6、TNF-α明显升高,提示炎症反应具有促进心房颤动的发生和持续的作用。
Objectives To explore the correlation between atrial fibrillation and high sensitive C-reactive protein(hs-CRP),IL-6,TNF-α. Methods Sexty nine patients with atrial fibrillation were divided into three groups:paroxysmal atrial fibrillation group(27 cases), persistent atrial fibrillation group(19 cases),permanent atrial fibrillation group(23 cases)and control group(sinus rhythm,21 cases). The serum hs-CRP,IL-6,TNF-αand left atrial diameter(LAd), ejection fraction(EF)of each group were measured by enzyme-linked immunosorbent assay(ELISA) and echocardiography respectively. Results Patients with paroxysmal, persistent and permanent atrial fibrillation had high levels of hs-CRP, IL-6, TNF-α when compared with the healthy subjects. Patients with persistent, and permanent atrial fibrillation had higher levels of hs-CRP, IL-6 and TNF-α, as compared with paroxysmal atrial fibrillation. No significant changes of hs-CRP,IL-6,TNF-αlevels were found in the persistent atrial fibrillation and permanent atrial fibrillation. The LAd of paroxysmal, persistent and permanent atrial fibrillation group was significantly higher than that of sinus rhythm group(P<0.01). The LAd of paroxysmal atrial fibrillation group was insignificantly greater than that of sinus rhythm group(P>0.05). Conclusions Serum hs-CRP, IL-6 and TNF-α in patients with atrial fibrillation significant increase indicating that the inflammatory reaction may promote the occurrence and maintenance of atrial fibrillation.
出处
《岭南心血管病杂志》
2007年第5期330-333,共4页
South China Journal of Cardiovascular Diseases
