摘要
目的探讨肿瘤标志物CEA、Cyfra21-1、NSE、Ca50联合检测在肺癌中诊断价值。方法应用电化学发光免疫分析及免疫放射分析法对214例肺癌、28例良性病变、32例健康人测定血清肿瘤标志物水平。结果214例肺癌血清肿瘤标志物CEA、Cyfra21-1、NSE、Ca50水平高于良性病变、健康组(P<0.01、P<0.05),Cyfra21-1、NSE分别在鳞癌,小细胞癌中高表达,差异显著(P<0.01);CEA和Ca50在腺癌中高表达(P<0.05);联合检测敏感性达94.4%.结论联合检测CEA、Cyfra21-1、NSE、Ca50可显著提高肺癌肿瘤标志物敏感性,为肺癌诊断提供有力依据。
ObjectiveObjecctive To Search the diagnostic value of the conjoined detection of Serum CEA、Cyfra21-1、NSE and Ca50 for lung Cancer. Methods Levels of Serum CEA、Cyfra21-1、NSEandCa50 were measured in 242 case of lung Cancer,benign lung disease 38 Case and 21 health person as control group by electrochemiluminescence immunoassay and immunoradiometric assay.Results The levels of serum CEA、Cyfra21-1、NSE and Ca50 in lung Cancer were higher than that of benigh lung diseases,and the control group(P<0.01 and P<0.05).The highest levels of serum Cyfra21-1 and NSE were detected in squamous cell lung carcinowa and SCLC respectively;and there were sighificantly different with the other patterns of lung cancer.The higher levels of serun CEA and Ca50.were determined in adencarcinom.The sensitivity of conjoined detection achieves 94.4%.Conclusion The conjoined detection of CEA、Cyfra21-1、NSE and Ca50 promote distinctively the sensitivity for lung cancer patients which will provide a scientific and reliable evidence for diagnosis of lung cancer.
出处
《中国实验诊断学》
2007年第11期1471-1472,共2页
Chinese Journal of Laboratory Diagnosis
