摘要
目的 研究热休克蛋白 70 (heatshockproteins 70 ,HSP70 )和细胞周期调节蛋白p2 7在粘液表皮样癌 (mucoepidermoidcarcinoma ,MEC)中的表达及其与临床病理特征的关系和对预后的影响。方法 应用免疫组化LSAB法检测 44例MEC中HSP70和p2 7表达 ,选用 10例多形性腺瘤 (plemorphicadenomas,PAs)作对照。结果 HSP70在MEC中表达明显高于在PAs中 (P <0 0 5 )。p2 7在MEC中表达显著低于在PAs中 (P <0 0 1)。在MEC和PAs中 ,HSP70和p2 7表达呈负相关 (P <0 0 5 )。在MEC中 ,HSP70表达与肿瘤组织学分级、临床分期、肿瘤大小呈正相关 (P <0 0 5 ) ,p2 7表达与组织分级、临床分期、肿瘤大小和淋巴结转移呈负相关 (P <0 0 5 )。多因素生存分析显示HSP70表达与不良预后显著相关。结论 HSP70可能是MEC独立的预后预测指标 ,p2
Objective To study the expression of heat shock proteins 70 (HSP70) and p27 in mucoepidermoid carcinoma (MEC) in relation to biological behaviour and prognosis Methods Immunohistochemical LSAB method was used to evaluate the expression of HSP70 and p27 in 44 MEC 10 Pleomorphic adenomas (PAs) were used as contrals Results The expression of HSP70 was significantly higher in MEC than in PAs, while p27 expression was significantl lower in MEC than in PAs There was a negative correlation between HSP70...
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2001年第6期70-73,96,共5页
Chinese Journal of Stomatology
基金
陕西省自然科学基金资助项目 ( 97SM42 )
