摘要
目的:观察知母活性成分知母皂甙元(ZMS)对学习记忆和脑中胆碱乙酰转移酶(ChAT)活性的影响.方法:腹腔内一次注射东莨菪碱建立小鼠拟痴呆模型,用避暗法及跳台法测定学习记忆能力,用3H-乙酰辅酶A掺入法测定脑组织ChAT活性.结果:ZMS可使东莨菪碱拟痴呆小鼠在学习记忆实验中的错误次数明显减少,潜伏期显著延长,并能显著增强脑内ChAT活性.结论:ZMS能够提高东莨菪碱拟痴呆小鼠的学习记忆能力,增强脑内ChAT的活性,但是,由于ZMS提高ChAT活性没有明显的量效关系,而且Tacrine也有类似作用,所以很可能不是直接提高ChAT活性,而是通过提高脑M受体密度实现的.
Objective: To observe the effects of ZMS on learning and memory abillity and on brain choline acetyltransferase activity.Methods: A single intraperitoneal injection of scopolamine was used to establish a dementia mouse model.The learning and memory a-bility was detected by step-through and sted-down tests. And the choline acetyltransferase activity in brain was determined by 3 H-acetyl-CoA incorporation analysis. Results: ZMS could significantly reduce wrongness frequences, prolong incubation period of scop...
出处
《中药材》
CAS
CSCD
北大核心
2001年第7期496-498,共3页
Journal of Chinese Medicinal Materials
