摘要
目的评价放射性125I粒子组织间永久性植入治疗软组织肿瘤的疗效和安全性。方法对12例软组织肿瘤共15个病灶(2个原发灶,13个局部复发或转移灶)行125I粒子永久性植入治疗。单个病灶植入粒子60颗(7~80颗),粒子活度0.6mCi(0.5~0.8mCi),肿瘤匹配周边剂量(MPD)140~160Gy。术后行质量验证。2个病灶质量验证不满意加行补充外照射,剂量为30、60Gy,分次剂量2.0Gy。结果中位随访时间17个月(3~34个月)。疼痛缓解率83%(5/6)。术后2个月实际临床获益率(完全缓解CR+部分缓解PR+疾病稳定SD)为93%(14/15)。1年及2年局部控制率均为83%。1年生存率72.9%,2年生存率62.5%,中位生存时间32个月。3例远处转移。5例死亡:1例死于肺转移,4例死于全身多器官衰竭。1例植入粒子后皮肤破溃未愈合,其他患者未出现明显的毒副作用。结论放射性125I粒子植入术单独或联合外照射治疗软组织肿瘤尤其是复发和转移性软组织肿瘤有效,方法简单、易行、微创、安全。
Objective To investigate the efficacy and safety of ^(125)I seeds interstitial implantation for soft tissue tumors. Methods Interstitial implantation of ^(125)I seeds was performed on 12 patients with soft tissue tumors (15 lesions including 2 primary lesions and 13 local recurrent or metastatic lesions). A mean of 60 (7-80) seeds were implanted into each lesion. The radioactivity of the ^(125)I seeds ranged from 0.5 to 0.8 mCi (mean, 0.6 mCi), and the matched peripheral doses (MPD) was 140-160 Gy. Quality ...
出处
《中国微创外科杂志》
CSCD
2008年第3期246-248,共3页
Chinese Journal of Minimally Invasive Surgery
