摘要
目的:观察肝癌及其癌旁组织中胰岛素样生长因子-Ⅰ受体(IGF-ⅠR)的表达及其临床病理学特征。方法:采用免疫组织化学方法,分别检测30例肝癌癌灶组及其自身对照的癌周组织中IGF-ⅠR的表达,并分析与其临床病理学特征及IGF-Ⅱ表达的关系。结果:肝癌IGF-ⅠR均呈较高表达,在肝癌癌灶为80.0%(24/30)及癌周组织表达43.3%(13/30),差异有统计学意义(2χ=8.53,P<0.01)。肝癌癌灶组中IGF-ⅠR阳性表达与肿瘤分化程度显著相关(P<0.05),而与肿瘤数目、大小、HBsAg阳性等无明显相关(P>0.05)。中、低分化程度肝癌组织中IGF-ⅠR表达率显著高于高分化组肝癌(P<0.05),且与IGF-Ⅱ表达具有正相关关系。结论:IGF-ⅠR在肝癌中过度表达,且与肝癌的形成和发展有关。
Objective: To investigate the expression and its clinical pathological alteration of insulin-like growth factor-I receptor(IGF-ⅠR) in different parts of human hepatocellular carcinoma(HCC) and its pericarcinoma.Methods: Using the immunohistochemistry,IGF-ⅠR expression was detected in 30 HCC and their non-cancerous tissues.The relationship was investigated between IGF-ⅠR and IGF-Ⅱ or their clinical pathological characteristics.Results: The stronger expression of IGF-ⅠR was found in either HCC or non-cancerou...
出处
《南通大学学报（医学版）》
2008年第3期169-171,共3页
Journal of Nantong University(Medical sciences)
基金
江苏省医学重点人才基金资助项目(RC2003100)
关键词
肝癌
胰岛素样生长因子Ⅰ受体
免疫组织化学法
表达
Hepatocellular carcinoma
Insulin-like growth factorⅠ receptor
Immunohistochemistry
Expression
