摘要
探讨血管紧张素转换酶(ACE)基因插入或缺失(I/D)多态性与糖尿病血瘀证的关系。选择糖尿病血瘀证患者105例、非血瘀证95例和对照组105例,应用聚合酶链式反应(PCR)方法检测ACE基因I/D多态性。结果显示:3组II、ID和DD基因型总的分布有显著性差异(P=0.047);经卡方分割,糖尿病血瘀证组ACE-DD基因型频率22.86%,高于非血瘀证组(12.63%)和对照组(8.57%),差异显著(P=0.004);多项logistic回归分析,ACE-DD型人群患糖尿病血瘀证的相对危险度为2.912。结论:ACE-DD基因型可能是糖尿病血瘀证发病的易感危险因素之一。
To explore the relationship between the insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) and blood stasis syndrome (BSS) in patients with diabetes mellitus (DM).The ACE I/ D genotype in 105 patients of DM of BSS (DM-BSS group),95 patients of DM of non-BSS (DM-non-BSS group) and 105 healthy subjects (control group) were determined by polymerase chain reaction (PCR) assay. The results showed that the constituent ratio of ACE II,ID,DD genotype was significantly different among three...
出处
《福建中医学院学报》
2007年第6期1-3,共3页
Journal of Fujian College of Traditional Chinese Medicine
基金
福建省卫生厅中医药科研课题(WZY0626)
关键词
糖尿病
ACE
基因
血瘀证
diabetes mellitus
angiotensin converting enzyme
gene
blood stasis