摘要
目的:探讨肿瘤抑制基因nm23、p53蛋白产物在鼻咽癌组织中异常表达与肿瘤临床分期、病理分级和淋巴结转移等肿瘤的生物学特征的关系。方法:应用免疫组织化学ABC方法检测42例鼻咽癌活检标本中nm23、p53蛋白的表达水平。结果:鼻咽癌组织中nm23和p53蛋白表达的阳性率分别为50.0%和45.2%,nm23蛋白表达与临床分期和病理分级呈正相关,而与鼻咽癌的淋巴结转移呈负相关(P<0.05)。p53蛋白表达与鼻咽癌的临床分期和分化程度呈正相关,而与肿瘤的淋巴结转移无关(P>0.05)。结论:nm23、p53蛋白的表达在鼻咽癌的侵润转移中起重要作用,p53表达与鼻咽癌组织临床分期、分化程度有关,鼻咽癌的淋巴结转移可能与多基因异常改变有关。
Objective:To study the relationship between the expression of the non metastasizing nm23 protein and the tumor supperssor gene p53 protein in nasopharyngeal carcinoma and its biological characteristic.Metheds:The expression of nm23 and p53 proteins in 42 cases of nasopharyngeal carcinoma were determined with immunohistochemistry.Results:The positive rates of expression for nm23 and p53 proteins were 50.0% and 45.2%,respectively.The nm23 expression was significantly correlated with the clinical stage,patholo...
出处
《华西医学》
CAS
2007年第4期717-718,共2页
West China Medical Journal
关键词
鼻咽癌
NM23蛋白
P53蛋白
nasopharyngeal carcinoma
nm23 protein
p53 protein
