摘要
目的:确定小剂量阿司匹林对年龄≥65岁的女性是否具有针对认知功能减退的保护作用。设计:此队列研究基于女性健康研究的全部两个分组。女性健康研究是一项随机化、双盲、安慰剂对照试验,探索在1992—1995年间小剂量阿司匹林用于心血管疾病和癌症一级预防的作用。受试者:6377例年龄≥65岁的女性。
Objective: To determine whether low dose aspirin protects women aged 65 or more against cognitive decline. Design: Cohort study within both arms of the women s health study,a randomised,double blind,placebo controlled trial of low dose aspirin for the primary prevention of cardiovascular disease and cancer,1992-5. Setting: Women s health study,1998-2004. Participants: 6377 women aged 65 or more. Interventions: Low dose aspirin(100 mg on alternate days) or placebo for a mean of 9.6 years. Main outcome meas...
