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早期应用肺表面活性物质治疗新生儿呼吸窘迫综合征疗效观察

Observing the Effect of Pulmonary Surfactant Early Bringing Down Neonatal Respiratry Distress Syndrome
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摘要 目的:探讨肺表面活性物质(PS)早期给药对极低出生体重儿呼吸窘迫综合征(NRDS)疗效的观察。方法:对19例患NRDS的极低出生体重儿给予PS治疗并同时进行临床对照实验。结果:NRDS患儿给药后24h PO2/FiO2较用药前明显改善,差异显著(P<0.05),呼吸机参数(除PEEP外)明显下降,差异有显著性意义(P<0.05)。结论:对于极低出生体重儿NRDS,早期给予PS治疗可明显改善近期预后,提高存活率。 Objective: To explorei effect of pulmonary surfactant(PS) in the treatment of neonatal respiratry dstress syndrome(NRDS) in early phase.Method:19 examples low birth weight infants with NRDS were treated with pulmonary surfactant in this controlled clinical trail.Result:After given PS 24 hours,the PO2/FiO2 and parameter of respirator utilization ascended significantly,there were significant difference(P<0.05).Conclusion: The strategy of surfactant treatment in early phase can significantly improve the survival of very low birth weight infants with NRDS.
出处 《河北医学》 CAS 2007年第3期314-316,共3页 Hebei Medicine
关键词 肺表面活性物质 呼吸窘迫综合征 极低出生体重 Pulmonary Surfactant Neonatal respiratory distress syndrome Born very low birth infant
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  • 1封志纯,梁巧明,张帆.肺表面活性物质雾化吸入治疗RDS[J].国外医学(儿科学分册),1996,23(1):20-23. 被引量:11
  • 2[2]Brown DS,Bloom BT Cohen M,et al.Increased survival in low birh weight neonates given prophylactic surfactant[J].Perinatol,1998,18(6):431-435.
  • 3[3]Kresch MJ,Clive JM.Meta-analyses of surfactant replacement therapy of infants with weights less than 2000 grams[J].Perinatol,1998,18(4):276-283.

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