摘要
目的研究锌与维生素C对运动训练小鼠的协同抗氧化作用。方法将昆明种小鼠随机分为5组,每组6只,即生理盐水对照组、运动对照组、运动锌组、运动维生素C组、运动锌与维生素C联合组。运动锌组、运动维生素C组、运动锌与维生素C联合组分别每日按200mg/kg灌胃相同剂量的锌提取液、维生素C液、锌和维生素C混合液,灌胃体积为0.2ml/kg,生理盐水对照组、运动对照组分别灌胃相同剂量的生理盐水。3周后测定各组小鼠血液、肝和脑组织的超氧化物歧化酶(super-oxide dismutase,SOD)的活力和丙二醛(malondialdehyd,MDA)的含量。结果与运动对照组比较,运动锌组、运动维生素C组、运动锌与维生素C联合组小鼠血清、肝和脑组织的SOD活力显著增强,MDA含量明显降低,差异均有统计学意义(P<0.05),其中运动锌与维生素C联合组的结果更明显。结论锌和维生素C对运动训练小鼠有良好的协同抗氧化能力。
Objective To understand the synergistic effect of zinc and vitamin C on the anti-oxidative ability of sport training mouse. Methods 30 mice were randomly divided into 5 groups, blank control, normal saline solution, zinc , vitamin C and zinc + vitamin C. After 3 weeks of treatment, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in the serum, liver and brain were determined. Results Compared with the control, the activity of SOD in the serum, liver and brain of the mice treated with zinc and vitamin C significantly increased, the content of MDA showed a significant decrease, the combination of zinc and vitamin C presented the best effect. Conclusion Combination of zinc and vitamin C has a significant synergistic effect in improvement of anti-oxidative ability.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2007年第8期625-627,共3页
Journal of Environment and Health
关键词
微量元素
脂质过氧化
锌
维生素C
抗氧化性
自由基
Trace elements
Lipid peroxidation
Zinc
Vitamin C
Anti-oxidative ability
Free-radicals
