摘要
目的观察木瓜蛋白酶体内溶栓效果。方法根据Benes等方法,制备家兔脑动脉血栓模型,设置空白、阴性、阳性对照组,木瓜蛋白酶组及木瓜蛋白酶与纤溶酶原合用组,数字减影血管造影技术观察体内溶栓效果。结果木瓜蛋白酶与纤溶酶原混合液实验组与阳性对照组完全再通时间为90min,空白、阴性对照组及木瓜蛋白酶组24h内没有观察到再通现象。实验动物24h后处死解剖,均未见出血现象。结论木瓜蛋白酶在体内有溶栓作用。
Objective To observe the thrombolytic effect. Methods The model of cerebral artery thrombus was estabilished in rabbits according to Benes mothod. The rabbit were divided into blank control group, negative control group, positive control group, papain group and papain+plasminogen group. The thrombolytic effect was detected by digital subtraction radiography and angiography. Results The recanalization time of papain+plasminogen group and positive control group is 90min, No recanalization was found in blank control group, negative control group and papain group in 24h. Conclusions The papain maybe contain of plasminogen activator.
出处
《遵义医学院学报》
2007年第z1期1-3,共3页
Journal of Zunyi Medical University
基金
遵义市红花岗区科技局资助项目
遵红科2002(20)
