摘要
目的比较西酞普兰与文拉法辛治疗抑郁症的临床效果。方法应用CCMD-3关于抑郁症的诊断标准,分别对接受西酞普兰(30例)及文拉法辛(31例)治疗的抑郁症患者进行为期8周的观察。并应用HAMD、HAMA、CGI-S量表评估和比较两者的疗效及安全性。结果经8周治疗,西酞普兰有效率及显效率分别为96.7%、63%,与文拉法辛组(93.5%、78.1%)比较差异无显著性(P>0.05)。二者TESS总分亦无显著性差异(P>0.05)。结论西酞普兰与文拉法辛均为安全而起效快的抗抑郁药物,但后者有明显消化系统疾患及高血压患者慎用。
Objective To evaluate the efficacy of citalopram and Venlafavine in the treatment of depression. Methods Sixty-one depression patients were divided into two groups. According to CCMD-3 criterie were enrolled in this study. Thirty patients taking citalopram (20~40mg/d) and another 31 patients having venlafaxine (125mg/d) for eight weeks. All the patients were evaluated with HAMD, HAMA, CGI-S and TESS. Antidepressive effective was compared between 2 drugs. Results At the end of eight weeks, there were no significant difference between the effective rates and significent rates of citalopram group (96.7%, 63%) and those venlafaxine group (93.5%, 78.1%)(P>0.05). The incresae of TESS score were no significant defference between two groups (P>0.05). Conclusion Citalopram and venlafaxine is an effective and safe antidepressant, but major digestive system disorder and/or hypertension's patients take care administrative to venlafaxine.
出处
《中国健康心理学杂志》
2007年第3期260-261,共2页
China Journal of Health Psychology
