摘要
研究慢性肝病患者血清铁蛋白(SF)与血清肝纤维化指标(透明质酸HA、层粘连蛋白LN、血清Ⅲ型前胶原肽PⅢP、Ⅳ型胶原CⅣ)及病理分期的相关性。采用酶联免疫及放射免疫法,对85例慢性肝病患者检测SF及肝纤维化四项指标,并对其中50例慢性肝炎患者行肝穿活检。慢性肝病患者SF、肝纤维化四项指标与正常对照组比较差异显著,SF随慢性肝炎及肝硬化临床分型及Child-Pugh分级的逐渐加重而升高。SF随病理分期依次增高,与S0期比较P<0.01;SF与HA、LN、PⅢP、CⅣ具有相关性(r值为0.68,0.58,0.47,0.61)。提示肝铁代谢异常与肝纤维化的发生发展密切相关。对于判断肝纤维化的程度有一定的临床意义。
To study the relationship between levels of serum ferritin(SF) and the indexes of hepatic fibrosis,such as hyaluronic acid(HA),type Ⅲ procollage(PⅢP),Laminin(LN),type Ⅳ collagen(CⅣ) and pathobiologic stage,in patients with chronic hepatic disease.Serum samples from 85 patients with chronic hepatic disease were tested with MRIA and RIA for serum ferritin and fibrosis indexes including HA,LN,PⅢP and CⅣ.Thereinto 50 cases accepted liver biopsy for pathobiologic stage.The levels of serum ferritin and the fibrotic indexes increased gradually in pace with the progression of liver diseases and obviously higher than those in normal controls.The levels of serum ferritin were elevated with the progression of hepatic fibrotic stages(from S1 to S4 compared with S0,P<0.01).There were correlation between SF and HA,LN,PⅢP or CⅣ(r=0.68,0.58,0.47,0.61).The levels of serum ferritin and serum fibrotic indexes might play an important indicative role in differentiating hepatic fibrotic degrees.
出处
《临床肝胆病杂志》
CAS
2007年第3期179-180,共2页
Journal of Clinical Hepatology
