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组蛋白H2AX磷酸化与肿瘤放疗敏感性关系的研究进展 被引量：3

Relationship between phosphorylation of histone H2AX and tumor radiosensitivity
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摘要 目的:总结国内外关于组蛋白H2AX磷酸化与肿瘤放疗敏感性关系的研究现状。方法:应用检索Medline及维普期刊全文数据库检索系统,以'组蛋白、H2AX、磷酸化、DNA修复、肿瘤、放疗和敏感性'等为关键词,检索2000-01~2007-08相关组蛋白H2AX与放疗敏感性方面的文献。资料选择:对资料进行初选,组蛋白H2AX的生物学功能与肿瘤放疗敏感性的关系等方面的文献。纳入标准:1)关于组蛋白H2AX的生物学功能的研究。2)关于组蛋白H2AX磷酸化可以指示放疗敏感性的研究。3)关于组蛋白H2AX磷酸化与提高放疗敏感性的研究。资料提炼:粗选有百余篇关于组蛋白H2AX方面的文章,根据纳入标准,精选50篇文献,最后纳入分析24篇文献。结果:组蛋白H2AX在DNA发生双链断裂损伤时发生磷酸化,磷酸化的H2AX参与DNA损伤修复和维持基因组稳定性;由于γ-H2AX的数量与DNA损伤的数量存在一一对应的关系,因此,γ-H2AX可以作为低剂量电离辐射后衡量肿瘤放疗敏感性的指示器;通过抑制H2AX上游的激酶阻止H2AX被磷酸化,或直接抑制γ-H2AX在DNA修复进程中的功能,或应用潜在的电离辐射致敏剂,可以延长电离辐射后γ-H2... OBJECTIVE:To summarize what has been learned about histone H2AX phosphorylation and cancer radiotherapy sensitivity both in China and in other countries. METHODS: The papers were searched by key words of histone, phosphorylation, DNA repair, cancer, tumor, radiotherapy and sensitivity through the Medline and Weipu index systems from January 2000 to August 2007. Information choice: the biological function of histone H2AX and the cancer radiotherapy sensitivity. Inclusion criterion: 1)About the biological fun...
作者 曹明丽 陈可欣
机构地区 天津医科大学附属肿瘤医院流行病室
出处 《中华肿瘤防治杂志》 CAS 2008年第9期715-718,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 DNA损伤/辐射效应 组蛋白类/分析 综述文献 DNA damage/radiation effects histones/analysis review literature
分类号 R730.5 [医药卫生—肿瘤]
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参考文献3

二级参考文献67

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共引文献19

同被引文献24

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引证文献3

二级引证文献13

中华肿瘤防治杂志
2008年 第9期

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