摘要
采用自行设计的新型可降解仿生材料RGD多肽和β-TCP复合膜(PRGD)及PRGD与神经生长因子(NGF)共混膜(PNGF),研究其在周围神经缺损修复中对神经再生的作用。通过在Wistar大鼠体内实验,分别于3个月、6个月取材,对其再生神经进行形态学、组织学观察,并进行三头肌湿重比、电生理及免疫组化检测。研究结果显示,PRGD膜能有效桥接修复大鼠缺损的坐骨神经,具有良好的生物相容性,而PNGF膜能够有效促进大鼠坐骨神经再生,加速再生神经的成熟,其部分生理指标接近正常自体神经移植效果。
The effect of new type biomimetic materials,the composite membrane(PRGD) of RGD polypeptide and β-TCP and the blend membrane(PNGF) of PRGD and nerve growth factor(NGF),was researched on improving peripheral nerve regeneration for the repairing of peripheral nerve regeneration.After 3 and 6 months of Wistar rats experiment in vivo,the regenerated nerve was researched by the morphology and histology observation and examination of ratio of wet weight of musculus triceps,electrophysiological indexes and immunoh...
出处
《武汉理工大学学报》
EI
CAS
CSCD
北大核心
2008年第4期46-49,共4页
Journal of Wuhan University of Technology
基金
国家"973"计划(2005CB623905)
