摘要
运用正交实验研究了环氧丙烷(PO)开环合成2-氯-1-丙醇的反应,讨论了反应温度、PO和盐酸的进料摩尔比、PO和乙醚的稀释摩尔比、反应时间及反应时的搅拌速度等因素对反应的影响。并通过气相色谱-质谱对反应所涉及产物进行了分析。提出优化工艺条件为:反应温度控制在65℃左右,PO和盐酸的进料摩尔比为1:2~1:4,PO和乙醚的稀释摩尔比为1:1,反应时间7~9h。在此条件下的反应结果为:PO的转化率为73.98%,2-氯-1-丙醇的选择性为43.83%,收率为32.43%。
Synthesis of 2-chloro-1-propanol from propylene oxide (PO) by ring-opening reaction was studied, and the synthesized products were analyzed by GC-MS. The effects of several chief factors, such as reaction temperature, the feed-in ratio of PO versus hydrogen chloride, the dilution ratio of PO versus ether, reaction time and stirring speed, were investigated through orthogonal experiments, and the optimum process conditions were found. When controlling the reaction temperature at 65 ℃ and reacting for 7~9 h w...
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2008年第3期528-531,共4页
Journal of Chemical Engineering of Chinese Universities
关键词
环氧丙烷
开环反应
氯丙醇
工艺优化
propylene oxide
ring-opening reaction
2-chloro-1-propanol
process optimization
