摘要
控制胶珠或胶囊的尺寸是生物微胶囊在人工器官和细胞固定化应用方面的要求。建立了一种通过气流作用于针头出口处的液滴,来制备比较均一的、可控尺寸微胶囊的方法。通过对针尖出口处液滴的受力分析,建立了描述液滴尺寸和气体出口处流速之间关系的方程。通过该方程可以根据对胶珠(或胶囊)尺寸的需要,计算得到应该实际控制的气流速度。最后通过Alginate/Ca凝胶珠和NaCS/PDMDAAC微胶囊两种体系,在不同气流速度下获得的胶珠和胶囊尺寸,对建立的方程进行了实验验证,并同时对制得的胶珠和胶囊的尺寸分布进行了表征。实验结果表明,通过气流法可在1.0mm^2.6mm范围内获得尺寸较均一的胶囊和胶珠。
It is required to control the size of capsule or bead when it is going to be applied in artificial organ and cell immobilization. A method of preparing the size-controllable and uniform capsules or beads by using pin hole with superposed air was proposed. The correlating equation between the drop size and the superposed air velocity was established through the analysis of the forces acting on the liquid drop at the tip of the pin hole, and the air velocity needed for preparing the bead or capsule with a giv...
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2008年第3期466-470,共5页
Journal of Chemical Engineering of Chinese Universities
基金
国家自然科学基金(20676048)
福建省青年人才项目(2006F3080)
华侨大学高层次人才科研启动基金(06BS214)
