摘要
目的探讨骨孤立性浆细胞瘤(solitary plasmacytoma of bone,SPB)的临床病理特征、免疫表型、鉴别诊断及治疗。方法对1例锁骨孤立性浆细胞瘤进行光镜观察,免疫组化染色并结合文献进行复习。结果镜下肿瘤细胞核偏位,可见双核及多核瘤巨细胞,异型明显;该肿瘤术前已浸润周围软组织,形成肿块,术后迅速播散。免疫表型:瘤细胞表达VS38C及κ;Ki-67高表达。结论骨孤立性浆细胞瘤属少见病例,本例临床表现及病理形态较为特殊,需与弥漫性大B细胞性淋巴瘤、间变性大细胞淋巴瘤、低分化癌相鉴别。
Objective To study the clinicopathologic and immunohistochemical features,diffential diagnosis and treatment of solitary plasmacytoma of the bone.Methods Light microscopic and immunohistochemical results of solitary plasmacytoma of clavicle in one patients and related literature was reviewed.Results Microscopically,the tumor cells were marked atypia with an eccentric nuclei, conjugate nuclear and polynuclear giant tumour cells were seen. Before operation the tumor had infiltrated surrounding soft tissue and formed a mass; after operation the tumor cells spreaded quickly. Immunohistochemically, It was positive for VS38C andκ, Ki-67 was strongly positive.Conclusion Bone solitary plasmacytoma is rare. Clinical presentation and pathological features of this patients is even more special, which should be distinguished from diffuse large B-cell lymphoma, anaplastic large cell lymphoma and poorly differentiated carcinoma.
出处
《临床和实验医学杂志》
2006年第9期1279-1280,共2页
Journal of Clinical and Experimental Medicine
关键词
锁骨
孤立性浆细胞瘤
免疫表型
预后
Clavicle
Solitary plasmacytoma
Immunophenotye
Prognosis
