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阻塞性黄疸患者肝细胞中bcl-2基因的表达及意义

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摘要 目的 探讨阻塞性黄疸患者肝细胞凋亡及bcl-2基因表达情况.方法 应用原位DNA末端标记法检测肝细胞凋亡指数,免疫组织化学方法检测bcl-2基因表达情况.结果 阻塞性黄疸患者肝细胞凋亡指数及bcl-2基因表达均明显高于无黄疸者.黄疸较轻时,bcl-2基因大量表达,凋亡指数就较低.随着黄疸加深,肝细胞的bcl-2基因表达减弱,凋亡指数就升高.结论 肝细胞凋亡存在于阻塞性黄疸患者肝脏中,阻塞性黄疸患者肝细胞有bcl-2基因表达,bcl-2基因对肝细胞凋亡有抑制作用.
出处 《现代保健(医学创新研究)》 2006年第5期38-39,共2页
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  • 1An Gao Xu Shao Guang Li Ji Hong Liu Ai Hua Gan Research Laboratory of Digestive Disease,Huizhou Central People’s Hospital,Huizhou 516001,Guangdong Province,ChinaDr.An Gao Xu graduated from Guangdong Medical College in 1984.He is an associate physician-in-chief,specializing in the research and treatment of gastrointestinal and liver tumors.He has published 24 papers and 1 book..Function of apoptosis and expression of the proteins Bcl-2,p53 and C-myc in the development of gastric cancer[J].World Journal of Gastroenterology,2001,7(3):403-406. 被引量:91
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