摘要
目的探讨用东菱迪芙治疗不同时窗急性进展性脑梗死的疗效。方法前瞻性分析了进展性脑梗死400例,并随机平分为两组,治疗组用东菱迪芙,对照组用复方丹参注射液,两组病人分为0￣6h、7￣12h、13￣24h、25￣48h及49￣72h五个时窗段分析。结果在相同时间窗内比较,其神经功能缺损评分上,治疗组显著低于对照组(P<0.01),而治愈率和总有效率治疗组显著高于对照组(P<0.01)。结论东菱迪芙对24小时内的急性进展性脑梗死治疗是安全有效的,对72小时以内的进展性脑梗死也有不同程度疗效,时间窗越短疗效越好。
Objective To explore the effect of batroxobin in treatment of acute cerebral infarction (ACI) in different times.Methods A total of 400 patients were divided randomly into two groups, 200 cases of treating group were treated with batroxobin and 200 cases of control group were treated with salviae miltiorrhizae-compound injection in the study. These patients were allotted respectively to 0~6h, 7~12h, 13~24h, 25~48h and 49~72 hours group according to sick times. The initial intravenous infusion of batroxobin were 10 unit in 250ml of normal saline every day for two times in treating group. After two day, Subsequent 10 unit batroxobin were administrated intravenous infusion on the fourth, sixth and eighth day respectively every other day for three times.Results The marks of neurological functional impairment were markedly reduced the treating group than control group(P￡1/40.01), cure rate and total effective rate were markedly increased the treating group than control group in identical time window(P￡1/40.01).Conclusion This study demonstrates that the batroxobin in effective and safe for ACI beginning treatment within 24 hours of stroke onset, and it is also effective within 72 hours of stroke onset. The shorter time is, the better effect of thrombolytic therapy.
出处
《中国实用医药》
2006年第4期15-16,12,共3页
China Practical Medicine
关键词
急性脑梗死
东菱迪芙
神经功能缺损
Acute cerebral infarction
Batroxobin
Neurological functional impairment.
