摘要
目的:评价谷氨酰氨和丙氨酸二肽在重度颅脑损伤中治疗价值。方法:46例重度颅脑损伤患者随机分成G组和C组,分别接受含有和不含谷氨酰氨和丙氨酸二肽营养治疗。记录GCS变化、NICU的居住时间和死亡率;并发症和淋巴细胞计数。结果:1G组的NICU的治疗时间和死亡率时显低于C组(P<0.05),两组之间的GCS没有显著的差异(P>0.05)。2G组的肺感染和消化道出血的患者明显低于C组。(P<0.05)3两组的淋巴细胞计数C组明显低于G组。(P<0.05)。结论:谷氨酰胺和丙氨酸肽可明显提高重度颅脑损伤患者的对抗应激的能力和抗感染能力,降低死亡率,缩短监护室住院时间;但是对GCS的影响较小。
Objective: To evaluate the effectiveness of bipeptide of glutamate and alanine in severe trauma brain injury. Methods: 46 patients with severe traumatic brain injury were randomized into two groups, G group and C group. Group G received nutritional remedy with the bipeptide of glutamine and alanine and group C without it. Record GCS changes、discharge dates of NICU and mortality; the count of lymphocytes; related complications included lung infection and hemorrhage of alimentary tracts et al. Results: 1 Mortality and date in NICU in group G lower than these in group C, but no obvious difference in change of patients GCS between the two groups(P>0.05) 2 The cases with lung infection and alimentary tracts hemorrhage in Group G was less than those in group C.(P<0.05), 3 The count of lymphocyte in group G was more than tat group C(P<0.05), but no difference in other nutritional data. Conclusion: The bipeptide could increase ability of patients in severe TBI against stress, which also lowered mortality and shortened NICU dates. However Glutamate could do little on GCS of patients in our clinical trials.
出处
《中国伤残医学》
2006年第6期1-3,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
重度颅脑损伤
谷氨酰胺和丙氨酸二肽
营养
Severe traumatic brain injury
Bipeptide of glutamate and alanine
Nutrition
