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纤维连接蛋白在慢性肾小球肾炎中的临床应用 被引量:1

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摘要 目的探讨血清和尿液中纤维连接蛋白(Fibronectin,Fn)在慢性肾小球肾炎的发生和发展过程中起的作用。方法用酶联免疫吸附法(ELASA)检测慢性肾小球肾炎患者与正常对照组血清与尿液中的纤维连接蛋白(Fn)。结果慢性肾小球肾炎患者血清中的Fn显著低于正常对照组(P<0.01);尿液中的Fn明显高于正常对照组(P<0.01)。结论在慢性肾小球肾炎的病情迁延进展过程中,一方面由于各种原因导致血浆Fn的消耗增多和合成减少,而另一方面血清Fn水平的降低又会加速慢性肾小球肾炎的病情的进展,尿Fn升高则可反映肾小球滤过膜的损伤程度。因此检测血、尿Fn的变化对于探讨慢性肾小球肾炎的病情进展具有重要作用。
出处 《齐齐哈尔医学院学报》 2006年第16期1938-1939,共2页 Journal of Qiqihar Medical University
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