期刊文献+

艾滋病患者外周血淋巴细胞计数取代CD4^+T细胞计数监测HAART疗效 被引量:2

The total lymphocyte count in peripheral blood of patients of hemophilia co-infected with HIV and HCV may substitute the counting of CD4^+T cells for the evaluation of highly active anti-retroviral therapy
原文传递
导出
摘要 评价血友病合并人类免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)感染的患者接受高效抗逆转录病毒治疗(highly ac-tive anti-retroviral therapy,HAART)时总淋巴细胞计数(total lymphocyte count,TLC)与CD4+T淋巴细胞计数间的相关性。回顾性分析了61例接受HAART的血友病合并HIV和HCV感染的患者共885对TLC与CD4+T淋巴细胞计数间的相关性。TLC用于预测CD4+T淋巴细胞计数的敏感性、特异性和阳性预侧值分别在不同的TLC范围对应于CD4+T淋巴细胞计数<200个/mm3时和CD4+T淋巴细胞计数<350个/mm3时获得。结果885对TLC与CD4+T淋巴细胞计数间存在相关性(r=0.511,P<001)。TLC<1 600个/mm3对应CD4+T淋巴细胞计数<200个/mm3有62.8%的敏感性、68.1%的特异性、43.1%的阳性预测值;TLC<1 800个/mm3对应CD4+T淋巴细胞计数<350个/mm3有79.1%的敏感性、78.0%的特异性、72.5%的阳性预测值。TLC可以作为一种低廉的监测手段在AIDS患者接受HAART时用于估测CD4+T淋巴细胞计数,其敏感性、特异性和阳性预侧值在TLC<1 800个/mm3对应CD4+T淋巴细胞计数<350个/mm3时最为明显。 To assess the correlation of the total lymphocyte count(TLC) in peripheral blood of patients of hemophilia co-infected by HIV and HCV with the counting of CD4+T cells during highly active anti-retroviral therapy(HAART),a retrospective study was made to evaluate the correlation between TLC and counting of CD4+T cells.The sensitivity,specificity and positive predictive value of various TLC cutoffs were determined for the CD4+T cell counts below 200 mm3 and 350 mm3.Significant correlation was noted in 885 pair...
作者 董婕 孙洪清
出处 《现代免疫学》 CAS CSCD 北大核心 2008年第4期331-334,共4页 Current Immunology
关键词 总淋巴细胞计数(TLC) CD4+T淋巴细胞计数 血友病合并HIV和HCV感染 高效抗逆转录病毒治疗(HAART) 相关性 total lymphocyte count CD4+T lymphocyte count hemophilia with HIV/HCV co-infected highly active anti-retroviral therapy correlation
  • 相关文献

参考文献5

二级参考文献43

  • 1姜拥军,尚红,张子宁,耿文清,刁莹莹,代娣,韩晓旭,张旻,王亚男,刘静,王树祥,苏艳丽,王琪.中国HIV/AIDS患者NK细胞及NKT细胞变化的检测[J].中华微生物学和免疫学杂志,2005,25(1):52-55. 被引量:15
  • 2王辉,唐蔚,徐六妹,李丽雄,王火生,周伯平.艾滋病患者外周血T细胞亚群CD28、HLA-DR分子的表达及其临床意义[J].现代免疫学,2005,25(1):44-44. 被引量:2
  • 3邱志峰,李太生,阮桂仁,韩扬,谢静,左玲燕,李雁凌,王爱霞.有效抑制HIV复制下AIDS患者CD4+T淋巴细胞的动态变化[J].中国医学科学院学报,2006,28(3):386-390. 被引量:9
  • 4Camma C, Bruno S, Schepis F, et al. Retreatment with interferon plus ribavirin of chronic hepatitis C non- responders to interferon monotherapy: a meta- analysis of individual patient data[ J ]. Gut, 2002,51:864-869.
  • 5Papatheodoridis GV, Papadimitropoulos VC, Hsdziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus- reated cirrhosis: a meta- analysis[J] .Aliment Pnarmaool Ther, 2001,15:689- 698.
  • 6Kjaergard LL, Krogsgaard K, Gluud C. Interfern alfa with or without ribavirin for chronic hepatitis C: systematic review of randonmised trials[J].BMJ, 2001,323:1151 - 1155.
  • 7Alberti A, Benvegnu L. Management of hepatitis[J] .J Hepatol, 2003,38(Suppl1): S1014 - S1 18.
  • 8Poynard T, MdHutchison J, Davis GL, et al. Impact of interferon alfa - 2b and ribavirin on progression of liver fibrosiis in patients with chronic hepatitis C[J].Hepatology, 2000,32:1131 - 1137.
  • 9Booth JCL, O' Grady J, Neuberger J. Clinical guidelines on the mangement of hepatitis C[J]. Gut, 2001, 49(Suppl I ): il - i12.
  • 10Chander G, Sulkowski MS, Jenckes MW, et al. Treatment of chronic hepatitis C: a systemic review[J]. Hepatology, 2002, 36(5 Suppl 1 ):S135 - S144.

共引文献816

同被引文献31

引证文献2

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部