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2型糖尿病肾病患者血清C反应蛋白与非高密度脂蛋白胆固醇水平变化的关系探讨

C-reactive Protein and Its Relation to Level of Non-HDL-C in Type 2 Diabetic Nephropathy
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摘要 目的:探讨不同病程的糖尿病肾病(DN)患者C反应蛋白(CRP)与非高密度脂蛋白胆固醇变化的关系特点。方法:将296例2型糖尿病患者根据尿白蛋白排泄率(UAER)分为三组,分别测定其血清C反应蛋白(CRP)、血甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿白蛋白、空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1C),计算non-HDL-C并进行统计学分析。结果:尿白蛋白排泄率升高组CRP、TG、TC、LDL-C、non-HDL-C明显高于尿白蛋白排泄率正常组(P<0.05或P<0.01),血HDL-C明显低于尿白蛋白排泄率正常组(P<0.05或P<0.01),三组CRP、TG、TC、LDL-C、non-HDL-C水平随DN程度加重而升高,且CRP与non-HDL-C具有相关性。结论:CRP,non-HDL-C作为危险因子与糖尿病肾病的发生、发展密切相关。 Objective:To investigate the relationship between serum C-reactive protein(CRP) and Non-highdensity lipoprotein cholesterol(non-HDL-C) levels in patients with Type 2 diabetic nephropathy(DN).Methods:Two hundred and ninety six T2DM patients were divided into three groups according to urinary albumin excretion rate(UAER).Serum level of CRP,the fasting total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and glycosylated hemoglobin(HbA1c)...
出处 《青海医药杂志》 2008年第6期1-4,共4页 Qinghai Medical Journal
关键词 糖尿病肾病 C反应蛋白 非高密度脂蛋白胆固醇 Diabetic nephropathy C-reactive protein Non-highdensity lipoprotein cholesterol
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参考文献9

  • 1向红丁.1991-2000年全国住院糖尿病患者慢性并发症回顾性分析.中国糖尿病杂志,2002,10:30-32.
  • 2[2]Joss N,Paterson KR,Deighan cJ,et al.Diabetic nephropathy:how effective is treatment in clinical practice.Q J Med,2002,95(1):41-49.
  • 3[3]Friedman AN,Hunsicker L G,Selhub J.Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy.Atherosclerosis,2004,172(1):121-125.
  • 4何冰,韩萍,吕先科.2型糖尿病患者急性时相蛋白与糖尿病肾病的关系[J].中华内分泌代谢杂志,2003,19(4):260-262. 被引量:170
  • 5[5]Rosario RF,Prabhakar S.Lipids and diabetic nephropathy.Curr Diab Rep.2006 Dec;6(6):455-462.
  • 6[6]Kashiwazaki K,Hirano T,Yoshino G,et al.Decreased release of lipoprotein lipase is associated with vascular endothelial damage in NIDDM patients with Microalbuminuria.Diabeties Care,1998,21(11):2 016-2 020.
  • 7李健斋,王抒,曾平.非高密度脂蛋白胆固醇用于评估及预测冠心病危险[J].中华心血管病杂志,2004,32(11):963-966. 被引量:45
  • 8吴炯,郭玮,潘柏申,赵瀛.冠状动脉病变时非高密度脂蛋白胆固醇的临床应用[J].检验医学,2006,21(4):316-319. 被引量:21
  • 9[9]Mendll MA,Patel P,Ballam L,et al.C-reactive protein and its relation to cardiovascular risk factors:a population based cross sectional study.BMJ,1996,312(7 038):1 061-1 065.

二级参考文献23

  • 1Sniderman AD.Counterpoint To (measure apo) B or not to (measure apo)B:a critique of modem medical decision-making[J].Clin Chem,1997,43:1310-1314.
  • 2Nauck M,Warnick GR,Rifai N.Methods for measurement of LDL-cholesterol:a critical assessment of direct measurement by homogeneous assays versus calculation[J].Clin Chem,2002,48:236-254.
  • 3Abate N,Vega GL,Grundy SM.Variability in cholesterol content and physical properties of lipoproteins containing apolipoprotein B-100[J].Atherosclerosis,1993,104:159-171.
  • 4Frost PH,Havel RJ.Rationale for use of non-highdensity lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy[J].Am J Cardiol,1998,81:26B-31 B.
  • 5Bachorik PS,Ross JW.National Cholesterol Education Program recommendations for measurement of low-density lipoprotein cholesterol:executive summary.The National Cholesterol Education Program Working Group on lipoprotein measurement[J].Clin Chem,1995,41:1414-1420.
  • 6Assmann G,Schulte H,Funke H,et al.The emergence of triglycerides as a significant independent isk factor in coronary artery disease[J].Eur Heart J,1998,19:8-14.
  • 7Bittner V,Hardison R,Kelsey SF,et al.Non-highdensity lipoproteincholesterol levels predict five-year outcome in the bypass angioplasty revascularization investigation (BARI)[J].Circulation,2002,106:2537-2542.
  • 8Bos G,Dekker JM,Nijpels G,et al.A combination of high concentrations of serum triglyceride and nonhigh-density-lipoprotein-cholesterol is a risk factor for cardiovascular disease in subjects with abnormal glucose metabolism:the hoorn study[J].Diabetologia,2003,46:910-916.
  • 9Jiang R,Schulze MB,Li T,et al.Non-HDL cholesterol and apolipoprotein B predict cardiovascular disease events among men with type 2 diabetes[J].Diabetes Care,2004,27:1991-1997.
  • 10Pischon T,Girman CJ,Sacks FM,et al.Non-highdensity lipoprotein cholesterol and apolipoprotein B in the prediction of coronary heart disease in men[J].Circulation,2005,112:3375-3383.

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