摘要
目的观察芹菜根提取物对CCl4所致小鼠急性肝损伤的影响。方法60只昆明小鼠随机均分为正常对照组、模型对照组、阳性对照组、芹菜根大、中、小剂量组。大、中、小剂量组按10.0、5.0、2.5 g.kg-1灌胃芹菜根提取物,阳性对照组按15 mg.kg-1灌胃联苯双酯滴丸,正常对照组及模型对照组以等体积生理盐水灌胃,共7 d。第7天,模型对照组、阳性对照组和给药组按10 m.lkg-1sc 1%CCl4花生油溶液,正常组注射等体积生理盐水。测定各组小鼠血清中无门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT),并观察肝组织的病理改变。结果芹菜根提取物能显著降低CCl4所致小鼠血清中AST、ALT含量的升高(P<0.05)。结论芹菜根提取物对CCl4所致的小鼠急性肝损伤具有一定的保护作用。
OBJECTIVE To observe the effect of extracts from celery root on carbon tetrachloride induced acute liver injury mice.METHODS Sixty mice were randomly divided into normal control group,model control group,bifendate pills control group,high-dosage group,middle-dosage group and low-dosage group.The mice in the above groups were fed for 7 days.The drug groups were pretreated intragastrically with 10.0,5.0,2.5 g·kg-1 of extracts from celery root.Bifendate pills groups were pretreated intragastrically with 15 mg·...
出处
《华西药学杂志》
CAS
CSCD
北大核心
2008年第4期411-412,共2页
West China Journal of Pharmaceutical Sciences
关键词
芹菜根
急性肝损伤
保护作用
Celery root
Liver injury
Protective effect
