摘要
目的:探讨血浆同型半胱氨酸(Hcy)水平与血管性痴呆(VD)的相关性。方法:应用全自动生化分析仪用循环酶法检测37例VD患者的血浆Hcy浓度,并与39例非痴呆脑梗死患者作为同龄对照组血浆Hcy浓度进行比较,同时测定血浆叶酸及VitB12浓度,根据简易精神状态检查量表(MMSE)评分划分VD患者严重程度,分为轻度(20～24分),中度(10～19分),重度(10分以下)。结果:VD组血浆Hcy水平显著高于非痴呆脑梗死组(P<0.05),VD组血浆叶酸水平显著低于非痴呆脑梗死组(P<0.05),两组间VitB12水平无显著性差异(P>0.05),不同程度VD患者血浆Hcy、叶酸水平有显著性差异(p<0.05),VitB12水平无显著性差异(p>0.05)。结论:高同型半胱氨酸血症可能是VD发病的一个新的危险因素。
Objective:To study the relationship between plasma homocysteine(Hcy)levels and vascular dementia(VD)Methods:37 VD patients and 39 patients with nondemented cerebral infarction were recruited in the study.Their plasma total Hcy levels were measured using automatic biochemical analyzer with enzymatic cycle detection.Plasma folate and serum VitaminB12 were determined for all of them.The severity of cognition impairment in VD patients was classified by MMSE`s scores:mild(20～24 points),moderate(10～19 points)and ...
出处
《脑与神经疾病杂志》
2008年第3期200-201,222,共3页
Journal of Brain and Nervous Diseases
