期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

大肠癌预防方法的研究进展 被引量：1

下载PDF
导出
摘要 大肠癌包括直肠癌和结肠癌,是人类常见的恶性肿瘤。研究证实叶酸、甲硫氨酸、胆碱、纤维素及其分解产物段链脂肪酸、维生素D和矿物质钙等生物活性食物成分可预防大肠癌的发生;炎痛喜康、舒林酸等非甾体类抗炎药可预防腺瘤癌变;优化后的免疫法FOBT和全结肠镜检查是目前筛查大肠癌的主要方法;对有遗传性大肠癌家族史成员进行APC、LKB1/STK11、FHTT基因突变检测和hM-SH1、hMSH2免疫组化及微卫星不稳定性检测在预防大肠癌的发生中意义重大。
作者 相英花
机构地区 青海卫生职业技术学院生化教研室
出处 《青海医药杂志》 2008年第2期65-68,共4页 Qinghai Medical Journal
关键词 大肠 恶性肿瘤 预防 筛查
分类号 R735.34 [医药卫生—肿瘤]
  • 相关文献

参考文献16

  • 1[1]Parkin DM,Bray F,Ferlay J.et al.Global Cancer Statistics,CA Cancer J Clin,2005,55:74～108.
  • 2房静远,萧树东.生物活性食物成分预防大肠癌的发生[J].中华消化杂志,2006,26(10):716-717. 被引量：7
  • 3[3]Nagothu KK,Rishi AK,Jaszews ki R,et al.Folic acid-mediated inhibition of seram-induced activation of EGFR promater in colon cancer cells.Am J Pnysiol Gasyrointest Liver physiol,,2004,287:541～546.
  • 4[4]Choi Sw,Mason JB.Folate status:effects on pathways of colorectal carcinogenesis.J Nutr,2002,132:2 413～2 418.
  • 5[5]Barnes JD,Arhel NJ,Lee SS,et al.Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells.Apoptosis,2005,10:301～311.
  • 6[6]Nishihara H,Hwang M,Kizaka-kondon S,et al.Cyclic Amp promotes cAMP-responsive element-binding protein dependent induction of the cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK 1/2 and p38MAPK.J Biol Chem,2004,279:26 176～26 183.
  • 7[7]Glade MJ.Food,nutrition,and the prevention of cancer:a global perspective.Nutrition,1999,15:523～526.
  • 8[9]Rahme E,Barkun AN,Toubouti Y,et al.The cycloxygenase-2-selective inhibitors rofeexib and celecoxib prevent colorectal neoplasia occurrence and reoccurrence.Gastroenterology,2003,125:404～412.
  • 9郑树,蔡善荣,张苏展.重视结直肠癌高危人群的筛查[J].中华消化杂志,2006,26(6):361-363. 被引量：41
  • 10[11]佟志伟.中国癌症筛查及早诊早治探索(试行).北京:北京大学医学出版社,2005,34～46.

二级参考文献9

共引文献96

同被引文献19

  • 1Cole BF, Logan RF, Halabi S, et al. Aspirin for the chemoprevention of colorectal adenomas : meta-analysis of the randomized trials. J Natl Cancer Inst, 2009, 101 (4) :256-266.
  • 2Flossmann E, Rothwell PM. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet, 2007, 369 (9573):1603-1613.
  • 3Botetti C, Gallus S, La Vecchia C. Aspirin and cancer risk : an update to 2001. Eur J Cancer Pre, 2002, 11 (6) :535-542.
  • 4Neugut AL, Jacobson JS, De Vivo I. Epidemiology of colorectal adenomatous polyps. Cancer Epidemil Biomarkers Prey, 1993, 2 (2) : 159- 176.
  • 5Jing L, Yang KH, Tian JH, et al. Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr Cancer, 2010, 62(6) :719-727.
  • 6Baron JA, Cole BF, Saudler RS, et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med, 2003, 348 ( 10 ) : 891- 899.
  • 7Benamouzig R, Deyra J, Martin A, et al. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology, 2003, 125 (2) : 328 -336.
  • 8Logan RF, Grainge M J, Shepherd VC, et al. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology, 2008, 134 ( 1 ) :29-38 .
  • 9Sandler RS, Halabi S, Baron JA, et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med, 2003, 348(10) :883-890.
  • 10Zhang YL, Zhang ZS, Wu BP, et al. Early diagnosis for colorectal cancer in China. World J Castroenterol, 2002, 8( 1 ) :21-25.

引证文献1

青海医药杂志
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部