脑血管病血浆同型半胱氨酸水平测定及其临床意义被引量：1

The Clinical Significance of Homocysteine in Cerebrovascular Disease

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摘要目的研究同型半胱氨酸(Homocysteine,Hcy)与脑血管病的关系。方法采用荧光偏振免疫分析检测法(FPIA),测定75例脑梗死患者急性期、恢复期血浆Hcy浓度,30例脑出血患者血浆Hcy浓度;选取30例脑血管病病例进行药物干预治疗;对照组30例来自上述脑血管病人的家属,均为无脑血管病的健康人。结果①脑梗死、脑出血患者血浆Hcy浓度显著高于正常参考值(P<0.05),对照组与正常参考值差异无统计学意义;②脑梗死与脑出血患者血浆Hcy浓度比较差异无统计学意义(P>0.05);③脑梗死患者急性期与恢复期血浆Hcy浓度差异无统计学意义;④单因素相关分析显示Hcy水平与性别有相关性,与年龄无相关性。结论血Hcy增高与脑梗死和脑出血发生密切相关;选自脑血管病人家属的对照组也呈高Hcy血症,说明Hcy与高蛋氨酸饮食有关;Hcy与应激状态无关,是一稳定的指标;短期、中等剂量药物干预治疗能显著降低Hcy水平。 Objective To understand the relationships between homocysteine(HCY) and cerebrovascular disease.Methods The HCY levels were measured in 75 patients with cerebral infarction at acute stage and convalescene and 30 patients with apoplexy by fluorescence polarization immunoanalysis(FPIA).Thirty patients among them were treated with medicine.Thirty healthy family members without cerebrovascular diseases were selected as control group.Results 1) HCY levels of blood plasma in the cases with cerebral infarction and apoplexy were significant higher than that of normal reference value(P<0.05),there was no significant difference between control group and normal reference value.2) There was no difference in HCY level between cerebral infarction and apoplexy group(P>0.05).3) There was no difference in HCY level at acute stage and convalescene in patients with cerebral infarction.4) Single factor correlation analysis indicated that HCY level had some associativity with sex,but not with age.Conclusions HCY levels of blood plasma in patients with cerebrovascular disease are obviously higher than normal reference value.HCY level is also higher in the family members of the patients with cerebrovascular diseases.Probably,higher HCY is correlated with homomethionin diet.HCY has no relation with stringent state as a nonactive index.HCY level can be strikingly reduced by short-term medicine and medium dosage treatment.

作者郭涛杜彦辉

机构地区宁夏医学院附属医院神经内科

出处《宁夏医学院学报》 2005年第6期457-458,465,共3页 Journal of Ningxia Medical College

基金宁夏医学院科研基金(2004年)

关键词脑血管病同型半胱氨酸 cerebrovascular disease homocysteine Hcy

分类号 R743 [医药卫生—神经病学与精神病学]

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