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胃癌组织Cox-2和MMP-2与MMP-9蛋白表达及其临床意义的研究 被引量：13

Expressions and clinical significance of Cox-2,MMP-2 and MMP-9 proteins in human gastric carcinoma
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摘要 目的:探讨Cox-2、MMP-2及MMP-9蛋白在胃癌中表达、相互关系及临床意义。方法:采用免疫组化SP法检测96例胃癌组织及癌旁正常组织Cox-2、MMP-2和MMP-9蛋白表达。结果:胃癌组织中Cox-2、MMP-2及MMP-9阳性表达率分别为74.0%(71/96)、72.9%(70/96)及66.7%(64/96),皆明显高于癌旁正常组织(Cox-2、MMP-2及MMP-9阳性表达率分别为32.3%、30.2%和31.3%),P<0.001;三者的表达都与肿瘤发生部位、肿瘤浸润深度、临床分期及淋巴结转移呈明显的正相关,P<0.05,而与患者年龄、性别、肿瘤大小和分化程度无显著相关性,P>0.05;Cox-2与MMP-2、MMP-9蛋白表达呈明显的正相关性。结论:胃癌组织中存在Cox-2、MMP-2及MMP-9蛋白的高表达,Cox-2与MMP-2和MMP-9蛋白表达强度具有等级相关性。Cox-2蛋白可通过诱导MMP-2和MMP-9蛋白的表达上调,增加胃癌细胞的侵袭力,从而成为其促进胃癌浸润和转移的途径之一。 OBJECTIVE:To study the expressions and clinical significance of Cox-2,MMP-2 and MMP-9 proteins and their relationships with human gastric carcinoma.METHODS:Cox-2,MMP-2 and MMP-9 protein expressions were examined by immunohistochemistry in 96 cases of human gastric carcinoma and paracancerous normal tissues.RESULTS:The expression rates of Cox-2,MMP-2 and MMP-9 in gastric carcinoma tissues were 74.0%(71/96),72.9%(70/96)and 66.7%(64/96)respectively,which were significantly higher than those in paracancerous no...
作者 徐腾云 王晓秋 胡冰 何义富 胡长路 陈曼萍
机构地区 安徽医科大学附属省立医院肿瘤科
出处 《中华肿瘤防治杂志》 CAS 2008年第13期1003-1006,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 胃肿瘤/病理学 环氧化酶-2 金属蛋白酶-2 金属蛋白酶-9 免疫组织化学 gastric neoplasms/pathology cyclooxygenase-2 matrix metalloproteinase-2 matrix metalloproteinase-9 immunohistochemistry
分类号 R735.2 [医药卫生—肿瘤]
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二级参考文献119

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共引文献73

同被引文献143

引证文献13

二级引证文献87

中华肿瘤防治杂志
2008年 第13期

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