摘要
目的研究大鼠哮喘模型血清IgE、嗜酸性粒细胞(EOS)含量变化及重楼对其的影响。方法50只雄性SD大鼠随机分成对照组、哮喘组、重楼高剂量组(50g/kg)、重楼低剂量组(5g/kg)、地塞米松组5组,每组10只。用鸡清卵蛋白(OVA)致敏及诱发哮喘模型,用地塞米松和不同剂量的重楼干预治疗,对照组以生理盐水代替OVA。观察各组大鼠血中IgE和EOS含量以及支气管黏膜炎性变化。结果重楼高、低剂量组及地塞米松组大鼠哮喘症状缓解,组织水肿、上皮气道损伤等炎性反应状况明显减轻,外周血IgE水平降低,EOS比例减少,且重楼高剂量组改善优于重楼低剂量组,重楼高剂量组与地塞米松组差异无统计学意义(P>0.05)。结论重楼能有效缓解哮喘气道炎性反应,其机制可能与降低模型动物血清IgE和EOS有关。
Object To investigate the levels of serum IgE and EOS in asthmatic rats and the therapeutic effect of traditional Chinese medicine Chonglou.Methods The asthma model was built through sensitized with antigen(OVA).And after two weeks,attack the rats with aerosol OVA lasting for 7 days,24 hours after last sensitized.Fifty male rats with asthma were divided into control group,asthma group,high dose Chonglou group(50 g/kg),low dose Chonglou group(5 g/kg),and dexamethasone group.The expression of IgE and EOS were...
出处
《疑难病杂志》
CAS
2008年第9期528-530,577,共4页
Chinese Journal of Difficult and Complicated Cases
基金
广州市中医药
中西医结合科研计划课题资助项目(穗卫中[2000]1号)
