摘要
目的研究黄芪总黄酮(total navonoids 0f Astragalus,TFA)对扑热息痛所致小鼠肝损伤的预防功效。方法观察不同剂量(0、100、300、400、500 ms/kg)扑热息痛对c57BL/6J小鼠肝脏的损伤作用,比较经1天或5天(每天2次)的TFA预处理后对扑热息痛(400 mg/kg)所致肝损伤的防护作用。结果扑热息痛对小鼠肝损伤作用具有明显的量效关系。不同剂量的TFA对扑热息痛诱导小鼠肝损伤有不同程度的防护作用,其作用强度与药物浓度成正比；TFA可增加血清中SOD活性(P＜0．05)；高剂量的TFA(100mg/kg)具有降低肝组织中脂质过氧化物质的作用；此外,在相同TFA剂量下,5天组对扑热息痛诱导小鼠肝损伤的预防作用优于1天组。结论提示TFA可预防扑热息痛诱导的肝损伤,其预防作用与其使用时间有密切关系。
Objective To study the preventive effect of total flavonoids of Astragalus(TFA)on paracetamol- induced hepatic injury.Methods Different dosages of paracetamol(0,100,300,400 and 500mg/kg)on hepatic in- jury of c57BL/6J mice.The protective action induced by 400mg/kg paracetamol after 1 day or 5 days(twice/day) of TFA pretreatment in mice were compared.Results Paracetamol had obvious protection on hepatic injury of mice in a dose dependent manner.Different dosages of TFA showed protective action on mice induce...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第S1期149-151,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
黄芪总黄酮
扑热息痛
肝损伤
total flavonoids of Astragalus
paracetamol
hepatic injury
