摘要
目的探讨中药补中益气汤对A型肉毒毒素所致局灶性肌无力大鼠神经肌肉接头功能的影响。方法应用A型肉毒毒素造模制作大鼠肌无力模型,补中益气汤灌胃干预,并与模型组比较,电刺激单纤维肌电图(Stimu-SFEMG)观察用药前后颤抖(jitter)值(MCD)的改变。结果模型组MCD值在造模后20天、30天与造模后10天时比较有一定的降低,但差异无显著性；治疗组在用药后20天、30天的MCD值与造模后10天时比较均明显降低,差异有显著性(P＜0．01)。结论补中益气汤可以增强神经肌肉接头功能,因而可用于肉毒中毒的治疗。
Objective To explore the effect of Buzhong Yiqi Decoction(BZYQ)on neuromuscular junction function in creotoxin A intoxicated rat.Methods Myasthenia rat model was made by adopting creotoxin A,and BZYQ was intervened by gastrogavage and compared with the model group.Changes of jitter value(mean consecutive difference,MCD)before and after medication of BZYQ were observed by Stimu-single fiber electromyography (SFEMG).Results MCD value in the model group was reduced more obvious on the 20^(th) and the 30^(th) d...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第S1期9-11,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
补中益气汤
单纤维肌电图
A型肉毒毒素
Buzhong Yiqi Decoction
single fiber electromyography
creotoxin A
