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A Practical and Convenient Synthetic Process of 3-O-Decladinose-6-methyl 10,11-dehydrate-erythromycin-3-one-2'-acetate, an Important Intermediate of Ketolides Synthesis

A Practical and Convenient Synthetic Process of 3-O-Decladinose-6-methyl 10,11-dehydrate-erythromycin-3-one-2'-acetate, an Important Intermediate of Ketolides Synthesis
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摘要   3-O-Decladinose-6-methyl-10,11-dehydrate-erythromycin-3-one-2'-acetate (5) is an important intermediate for the synthesis of ketolides antibiotics.[1] In the improved synthetic method of compound 5, the more common reagent PCC[2]was used instead of the expensive reagent EDC and methanesulfonic anhydride.[3~4] In this way, compound 5 was obtained efficiently and economically in five steps from clathromycin 1 without being further purfied by column chromatography.……
出处 《有机化学》 SCIE CAS CSCD 北大核心 2004年第z1期366-,共1页 Chinese Journal of Organic Chemistry
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  • 1[1]Graul, A.; Castanet, J. Drugs Future 1998, 23(6), 591.
  • 2[2]Cheng, Y.-S.; Liu, W.-L.; Chen, S. Synthesis 1980, 223.
  • 3[3]Agouridas, C.; Denis, A.; Auger, J. et al. J. Med. Chem. 1998, 41, 4080.
  • 4[4]Agouridas, C.; Bonnefoy, A.; Chantot, J. F.; Le Martret, O.; Denis, A. EP 596802, 1994 [Chem. Abstr. 1995, 123, 56499].

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