大剂量雾化吸入糖皮质激素对慢性阻塞性肺疾病患者的影响被引量：1

Effect of High-dose Inhaled Glucocorticoid on Chronic Obstructive Pulmonary Disease

下载PDF

导出

摘要目的:观察大剂量雾化吸入激素时COPD急性加重(AECOPD)的疗效。方法:2007年1月至2008年6月住院的AECOPD患者72例,随机分为3组:治疗组Ⅰ:26例(男23例、女3例)平均年龄(73±5)岁,常规治疗+吸入布地奈德1 mg/bid×10天;治疗组Ⅱ:24例(男20例、女4例),平均年龄(72±6)岁,常规治疗+雾化吸入布地奈德2 mg/bid×10天;对照组22例(男15例、女7例),平均年龄(72±6)岁,常规治疗。比较三组治疗前后及治疗后三组间症状,肺功能(FEV1)的变化。用spss 11.0软件包对数据进行分析,治疗前后比较采用t检验,多组间比较采用方差分析,P<0.05为差异有统计学意义。结果:三组治疗前后比较,症状评分及FEV1值均有显著性差异(P<0.05);与对照组比较,治疗组Ⅰ及治疗组Ⅱ的症状评分,FEV1值均有显著性差异(P<0.05);治疗组Ⅰ及治疗组Ⅱ比较,症状评分及FEV1值均无显著性差异(P>0.05)。结论:大剂量雾化吸入激素(布地奈德1 mg/bid)可减轻AECOPD临床症状,改善肺功能。但再大剂量的雾化吸入激素(布地奈德2mg/bid),对AECOPD临床症状及肺功能无进一步改善。 Objective:To observe the effect of high-dose inhaled glucocorticoid in the treatment of acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Methods:We have chosen seven-two hospital patients with AECOPD(from January 2007 to June 2008)for the study.Patients were randomly allocated to one of the three groups,that is,CUREI(n=26),CUREII(n=24),or PLACEBO(n=22).The CRUEI group received conventional therapy and budesonide(BUD) nebulized suspension 1mg every 12h for 10d.The CUREII guoup was treated...

作者陈宇洁董桂英杨凌麟

机构地区四川省第四人民医院呼吸内科

出处《华西医学》 CAS 2008年第5期1115-1116,共2页 West China Medical Journal

关键词糖皮质激素雾化吸入治疗慢性阻塞性肺疾病 glucocorticoid inhale chronic obstructive pulmonary disease

分类号 R563.9 [医药卫生—呼吸系统]

引文网络
相关文献

参考文献5

1[3]Gan WQ,Man SF,Senthilselvan A,et al.Association between chronic obstructive pulmonary disease and systemic inflammation:a systematic review and a meta-analysis[J].Thorax,2004,59:574-580.
2[4]Saetta M,D;stefano A,Maestrellip,et al.Airaway eosinophilia in chronic bronchitis during exacerbations[J].Am J Respir Crit Care Med,1994,150(6pt 1):1646-1652.
3[5]Paggiaro PL Dahle R,Bakran I,et al.Muluticentre randomizod placebo controlled trial of inhaled flaticasone propionate,in patients with chronic obstructive pulmonary disease[J].Lancet,1998,351:773-780.
4王建丽.吸入糖皮质激素治疗稳定期慢性阻塞性肺病的临床研究进展和评价[J].中国医院用药评价与分析,2006,6(4):203-205. 被引量：3
5[7]Maltais F,ostinelli J,Bourbeau J,et al.Comparison of nebulized,budesonide and oral prednisolone with Placebo in the treatment of acute exacerbations of chronic ob structive pulmonary disease:a randomized controlled trial[J].Am J Respir Crit Care Med,2002,165:698-703.

二级参考文献14

1Pauwels RA,Buist AS,Calverley PMA,et al.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease.NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary[J].Am J Respir Crit Care Med,2001,163:1 256.
2Burge PS,Calverley PM,Jones PW,et al.Randomised,double blind,placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease:the ISOLDE trial[J].BM J,2000,320:1 297.
3Pauwels RA,Lofdahl CG,Laitinen LA,et al.Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking:european respiratory society study on chronic obstructive pulmonary disease[J].N Engl J Med,1999,340:1 948.
4Vestbo J,Sorensen T,Lange P,et al.Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease:a randomised controlled trial[J].Lancet,1999,353:1 819.
5Sin DD,Tu JV.Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2001,164:580.
6Suissa S.Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease-immortal time bias in observational studies[J].Am J Respir Crit Care Med,2003,168:49.
7Kiri VA,Pride NB,Soriano JB,et al.Inhaled corticosteroids in COPD:results from two observational designs free of immortal time bias[J].Am J Respir Crit Care Med,2005,172:460.
8Sutherland ER,Allmers H,Ayas NT,et al.Inhaled corticosteroids reduce the progression of airflow limitation in chronic obstructive pulmonary disease:a metaanalysis[R].Thorax,2003,58:937.
9Highland KB,Strange C,Heffner JE.Long-term effects of inhaled corticosteroids on FEV1 in patients with chronic obstructive pulmonary disease:a meta-analysis[R].Ann Intern Med,2003,138:969.
10Alsaeedi A,Sin DD,McAlister FA.The effects of inhaled corticosteroids in chronic obstructive pulmonary disease:a systematic review of randomized placebo-controlled trials[R].Am J Med,2002,113:59.