高同型半胱氨酸血症与颅内外血管狭窄的相关性研究被引量：18

Study of relationship between hyperhomocysteinemia and intracranial and extracranial vascular stenosis

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摘要目的探讨缺血性脑血管病患者高同型半胱氨酸(Hcy)血症与颅内外血管狭窄的关系。方法应用全自动生化分析仪,用循环酶法检测405例缺血性脑血管病患者血清Hcy水平,同时检测血清叶酸、维生素B12水平,应用经颅多普勒(TCD)检测所有患者的颅内血管,应用双功能彩色多普勒检测颅外血管。根据检测结果将颈内动脉(ICA)分为:正常、轻度狭窄(<50%)、中度狭窄(50%~69%)、重度狭窄(70%~99%)、闭塞;大脑中动脉(MCA)分为:正常、中度狭窄(50%~69%)、重度狭窄(70%~95%)、极度狭窄(>95%)。结果有颅内外血管狭窄组血清Hcy水平显著高于无颅内外血管狭窄组(P<0.01),血清叶酸水平显著低于无颅内外血管狭窄组(P<0.05),血清维生素B12水平两组间差异无统计学意义(P>0.05);ICA、MCA不同程度狭窄患者间血清Hcy水平差异有统计学意义(均P<0.01),血清叶酸水平差异有统计学意义(均P<0.05),维生素B12水平差异无统计学意义(均P>0.05);Hcy水平与ICA、MCA狭窄程度呈正相关(r=0.356,P<0.01;r=0.345,P<0.01);血清叶酸水平与ICA、M... Objective To study the relationship between hyperhomocysteinemia and intracranial and extracranial vascular stenosis in patients with ischemic cerebrovascular disease.Methods 405 patients with ischemic cerebrovascular disease were chosen to detect their serum homocysteine(Hcy) concentrations using automatic biochemical analyzer by enzymatic cycle detection,and the levels of serum folate and Vitamin B12 were detected .The intracranial vascular were detected by Transcranial Doppler, and the extracranial vascu...

作者庄爱霞刘华姜玉龙葛中林曾庆宏

机构地区江苏连云港市第二人民医院神经内科

出处《临床神经病学杂志》 CAS 北大核心 2008年第4期256-259,共4页 Journal of Clinical Neurology

关键词动脉粥样硬化同型半胱氨酸叶酸维生素B12 arteriosclerosis homocysteine folate Vitamin B12

分类号 R743.3 [医药卫生—神经病学与精神病学]

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