摘要
目的:探讨血脂异常及ApoE基因多态性与早发冠心病的关系及疾病的遗传易感性。方法:检测63例具有早发冠心病家族史的同胞和49例年龄、性别相匹配的健康对照者的血脂水平,聚合酶链式反应（PCR）和HhaI酶切法测定ApoE基因多态性。结果:整体血脂水平上同胞组与对照组比较差异显著（P<0.01）。本研究只发现3种常见ApoE基因型ε3/3、ε2/3和ε4/3,两组在基因型频率和等位基因频率分布上无统计学差异（P>0.05）;两组中不同基因型亚组间血脂水平无显著差异,ε3/3基因型亚组中同胞组与对照组比较,血脂水平有显著差异（P<0.01）。结论:具有早发冠心病家族史的同胞具有明显时血脂代谢紊乱,但ApoE基因多态性不是早发冠心病独立的危险因素。
Objective: Our purpose was to study the role of lipid levels and gene polymorphisms of apolipoprotein E ( ApoE) in siblings with family history of premature coronary heart disease. Methods: Subjects including 63 siblings whose brothers had suffered myocardial infarction before 55 years and 49 unrelated healthy controls received questionnaires, physical and biochemical examinations, and genotype analysis. Results; As a whole, the lipid variables of siblings with family history of premature coronary heart disease were significantly higher than those of controls ( P < 0.01) . There were only 3 genotypes presented, ε3/3, ε2/3, ε4/3. No statistically significant difference was observed in ApoE allele and genotype distribution ( P >0.05) between the two groups. Among the 3 subgroups according to different genotypes, there was no significant difference in lipid levels. In ε3/3 subgroups, TC, TG, LDL-C in siblings group were significantly higher than those in controls ( P <0. 01). Conclusion: The siblings with family history of premature coronary heart disease are being in the dislipidemic status. Gene polymorphisms of ApoE are not independent risk factor for premature coronary heart disease.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2002年第z1期6-8,13,共4页
Journal of China Medical University
关键词
载脂蛋白E
早发冠心病
家族史
apolipoprotein E
premature coronary heart disease
family history
