摘要
采用RT-PCR法、化学比色法对60例经纤维支气管镜活检的肺癌组织及20例非癌组织进行酸性各胱甘肽S-转移酶(GST-π)检测,并动态检测肺癌患者化疗前后血浆GST-π活力。结果显示GST-π在肺癌组织中的表达阳性率45％(27/60)明显高于非癌组织的表达阳性率13.3％(3/20),腺癌阳性率最高64.7％(11/17),鳞状细胞癌次之45.5％(15/33)、小细胞未分化癌无阳性表达。肺癌组织中GST-π的表达与血浆GST-π活力呈正相关(P<0.05)。肺癌患者血浆GST-π水平明显高于对照组,与疗效呈正相关(P<0.05)。肺癌GST-π基因表达及化疗前后血浆GST-π活力变化对肺癌化疗方案的选择及疗效判断均有一定指导意义。
The tissne GST-π and the plasma GST-π level of 60 lung cancer patients and 20 non-cancerpatients were detected by reverse transcription-polymerase chain reaction (RT-PCR) and chemochromatometryresptctively. The positive rate expression of GST-π gene in lung cancer tissues (45%)was higher than that of thenon-carcinomatous tissues (13. 3%). The positive rate of adenocarcinoma was 64. 7% (11/17), epidermoidcarcinoma was 45. 5 % (15/33),small cell undifferentiated carcinoma was negative expression. But no corre...
出处
《山东医药》
CAS
北大核心
2002年第30期5-7,共1页
Shandong Medical Journal
基金
山东省卫生厅立项课题(No.1997CA1DBA4)
