摘要
目的探讨年轻女性子宫内膜癌临床发病特点,探讨预防、早期诊断及合理治疗方法。方法回顾性分析1993年3月～2006年12月该院治疗的子宫内膜癌患者的临床资料,以其中25例年轻女性患者(≤40岁)为病例组,以248例50岁以上患者为对照组,进行病例对照研究。结果病例组月经不调15例(60%),不孕8例(32%),对照组既往月经不调38例(15.3%),不孕6例(2.4%),差异均有显著性(P<0.001)。病例组子宫内膜样腺癌占96%,其中细胞高分化13例(52%),中分化11例(44%),低分化1例(4%)。ER(+)19例(79.1%),PR(+)21例(87.5%)。对照组子宫内膜样腺癌占68.4%,细胞高分化23例(13.6%),中分化114例(67.4%),低分化32例(18.9%)。ER(+)86例(50.8%),PR(+)92例(54.3%)。差异均有显著性(P<0.001)。病例组中Ⅰ期患者20例(80%),对照组Ⅰ期患者125例(50.2%)。差异有显著性(P<0.01)。结论年轻患者更多有月经不调、不孕、多囊卵巢综合征。发病期别早,细胞高分化,主要为激素依赖型。临床治疗效果好,预后好,早期低危型年轻患者可以考虑保留卵巢功能及生育功能。积极治疗月经失调应该对年轻子宫内膜癌的发生起到一定预防作用。
Objectives To discuss the clinical features, prevention measures, early diagnosis and reasonable therapy of endometrial cancer in young females.Methodsclinical data of in-patients with endometrial cancer from March 1993 to December 2006 were analysed retrospectively.25 of the in-patients with endometrial cancer who were younger than 40-year-old were concluded as group and 248 in-patients who were older than 50 as control group.Case-control study was applied.ResultsThe number of patients complicated with men...
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第20期3053-3055,3062,共4页
China Journal of Modern Medicine
关键词
子宫内膜肿瘤
年龄因素
卵巢功能
预防
endometrial cancer
age factor
ovarian function
prevention
