摘要
目的探讨内毒素在大鼠肝硬化发生发展中的作用。方法采用饮用０．０３％硫代乙酰胺（ＴＡＡ）四个月复制伴有肠源性内毒素血症的肝硬化大鼠模型，观察ＴＡＡ与ＴＡＡ＋内毒素（ＬＰＳ）对肝组织胶原蛋白含量的影响，并测定血浆与肝组织匀浆的肿瘤坏死因子α （ＴＮＦ α）、内皮素（ＥＴ－１）、一氧化氮（ＮＯ）与丙二醛（ＭＤＡ）含量。结果 ＴＡＡ组与ＴＡＡ＋ＬＰＳ组大鼠血浆与肝组织的ＴＮＦ α、 ＥＴ－１、 ＮＯ、 ＭＤＡ与肝组织胶原蛋白含量均明显高于正常对照组。结论内毒素可加剧肝纤维增生并发展为肝硬化。
Objective To explore the effect of endotoxin on the development of cirrhosis. Methods The cirrhosis model with intestinal endotoxemia was made by oral intake of 0.03% thioacetamide for four months to observe the effect of endotoxin on the hepatic collagen contents in both thioacetamide and thioacetamide+ lipopolysaccharide groups and to detect the contents of tumor necrosis factor α (TNF α ), endothelin-1 (ET-1), nitric oxide (NO), and malondialdehyde (MDA) in the plasma and the hepatic homogenate. Results...
出处
《中华肝脏病杂志》
CAS
CSCD
2001年第S1期21-23,共3页
Chinese Journal of Hepatology
关键词
肝硬化
硫代乙酰胺
脂多糖
肿瘤坏死因子Α
大鼠
Hepatic cirrbosis
Thioacetamide
Lipopolysaccharide
Tumor necrosis factor α
Rats
