摘要
免疫有天然免疫和获得性免疫两种类型 ,它们有不同的机制和起源。天然免疫可识别某些“非己”细胞或分子并加以清除 ;获得性免疫则对分子抗原表位进行识别 ,按抗原提呈细胞等有无协同信号 (发育阶段 /类型 )而有所区别。两者有不同的生物学起源与意义 ;天然免疫源于防御入侵者的需求 ,获得性免疫则源于系统及个体自身发育中调节细胞发育的需求。两者嫁接性混合进化形成了复杂的可识别“自己 /非己”的免疫系统 ,并留下了神奇的机制。
Immunity can be divided into innate and adaptive types,each with a different mechanisms and origin. The innate type can directly identify 'non self' cells or molecules and destroy them. The adaptive type can recognize the molecule with epitopes but distinguish them by combining co stimulators on the antigen presenting cell of a development phase. The biological significances of innate immunity and adaptive immunity are totally different. The former was originated from the requirement of defending self against invaders and the latter with the regulating requirement of cells development in phylogeny and ontogeny of vertebrates. The complex self nonself recognition and distinction feature of immune system were formed by a mixed evolution with grafting each other,which appeared as a mystic mechanism.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2001年第z1期20-23,共4页
Immunological Journal
关键词
天然免疫
获得性免疫
识别
区别
进化
起源
innate immunity
adaptive immunity
recognition
distinction
evolution
origin
