摘要
目的:探讨下丘脑-垂体-甲状腺轴内分泌激素变化在脑梗塞(Cerebral infarction)病因中的作用。方法:研究对象按是否患脑梗塞和是否存在脑梗塞危险因素共分3组,即脑梗塞组、脑梗塞高危组、正常对照组。用放射免疫法检测血清中三碘甲状原氨酸(T3)、甲状腺素(T4)、促甲状腺素(TSH)、抗甲状腺球蛋白抗体(TGA)、抗甲状腺微粒抗体(TMA)水平,用独立样本t检验比较各组间差异。结果:脑梗塞组与脑梗塞高危组和正常对照组相比,血清中T3、T4水平显著下降,有显著性差异(P<0.01);而血清TSH水平明显升高,差异有显著性(P<0.01);与正常对照组相比,脑梗塞高危组血清中T3水平明显升高,两者相比有显著性差异(P<0.01),血清中T4水平呈升高的趋势,两者比较,无显著性差异(P>0.01);脑梗塞高危组中血清TSH水平较正常对照组低,两者比较,没有显著性差异(P>0.01)。结论:本研究提示脑梗塞患者及脑梗塞高危人群中存在下丘脑-垂体-甲状腺轴功能异常。
Objective:To find the effect of the abnormity of hypothalamus-pituitary-hypothyroid axis on cerebral infarction onset. Methods: Objects were divided into 3 groups: cerebral infarction group(CIG)、persons with cerebral infarction risk factor group(CIRG) and control group(CG) .The concentration of serum T3、T4、TSH、TGA and TMA on an empty stomach in each group were measured respectively by radioimmunoassay,and results were compared between each two groups by using Student t test. Results:Compared with CIRG and CG,the levels of T3、T4 in the sample of CIG were lower,and the level of TSH were higher,and there was distinctly difference(P<0.01);The level of T3 in CIRG was higher than that of CG,and there was distinctly difference(P<0.01);Compared with CG, the level of T4 was higher and the level of TSH was lower in CIRG,but there was no distinctly difference between CIRG and CG(P>0.01). Conclusion:This study indicated that the function of hypothalamus-pituitary-hypothyroid axis was abnormity in patients with cerebral infarction and those persons with cerebral infarctive risk factor.
出处
《重庆医科大学学报》
CAS
CSCD
2008年第z1期82-84,共3页
Journal of Chongqing Medical University
关键词
下丘脑-垂体-甲状腺轴
急性脑梗塞
Hypothalamus-pituitary-hypothyroid axis
Acute cerebral infarction
